Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography

Alexander I. Kholodnykh, Irina Y. Petrova, Massoud Motamedi, Rinat Esenaliev

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm-1 and about 20% in the range up to 40 mm-1. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.

Original languageEnglish (US)
Pages (from-to)210-221
Number of pages12
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume9
Issue number2
DOIs
StatePublished - Mar 2003

Fingerprint

Optical tomography
attenuation coefficients
tomography
Tissue
Multiple scattering
scattering
high resolution
Systematic errors
systematic errors
Lenses
Skin
Optical properties
lenses
Imaging techniques
optical properties
sensitivity
Experiments

Keywords

  • Medical diagnostics
  • Noninvasive monitoring
  • Optical coherence tomography (OCT)
  • Tissue optical properties

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography. / Kholodnykh, Alexander I.; Petrova, Irina Y.; Motamedi, Massoud; Esenaliev, Rinat.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 9, No. 2, 03.2003, p. 210-221.

Research output: Contribution to journalArticle

@article{62cc6ecff48a4144988d28810905d2df,
title = "Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography",
abstract = "Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5{\%}-10{\%} in the range from 0.5 to 17 mm-1 and about 20{\%} in the range up to 40 mm-1. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.",
keywords = "Medical diagnostics, Noninvasive monitoring, Optical coherence tomography (OCT), Tissue optical properties",
author = "Kholodnykh, {Alexander I.} and Petrova, {Irina Y.} and Massoud Motamedi and Rinat Esenaliev",
year = "2003",
month = "3",
doi = "10.1109/JSTQE.2003.814194",
language = "English (US)",
volume = "9",
pages = "210--221",
journal = "IEEE Journal of Selected Topics in Quantum Electronics",
issn = "1077-260X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "2",

}

TY - JOUR

T1 - Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography

AU - Kholodnykh, Alexander I.

AU - Petrova, Irina Y.

AU - Motamedi, Massoud

AU - Esenaliev, Rinat

PY - 2003/3

Y1 - 2003/3

N2 - Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm-1 and about 20% in the range up to 40 mm-1. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.

AB - Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm-1 and about 20% in the range up to 40 mm-1. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.

KW - Medical diagnostics

KW - Noninvasive monitoring

KW - Optical coherence tomography (OCT)

KW - Tissue optical properties

UR - http://www.scopus.com/inward/record.url?scp=0242493238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242493238&partnerID=8YFLogxK

U2 - 10.1109/JSTQE.2003.814194

DO - 10.1109/JSTQE.2003.814194

M3 - Article

AN - SCOPUS:0242493238

VL - 9

SP - 210

EP - 221

JO - IEEE Journal of Selected Topics in Quantum Electronics

JF - IEEE Journal of Selected Topics in Quantum Electronics

SN - 1077-260X

IS - 2

ER -