Acetaminophen hepatotoxicity

T. A. Broughan, R. D. Soloway

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To determine the influence of psychosocial factors in accidental and deliberate acetaminophen overdose, we reviewed the charts of 207 overdose patients, and 48 met our criteria for acetaminophen toxicity. Two patients died. A psychiatric history was present in 75%, and 25% had a previous or subsequent suicide attempt. A substance abuse history was elicited from 46%, and 36% of adolescent teenagers had a teen pregnancy. The mean time to starting N-acetylcysteine was 18.5 hr. Delayed N-acetylcysteine administration led to higher transaminase levels. Alcohol abuse was associated with a longer hospital stay. Mean AST was 8860 IU/liter in the accidental and 3013 IU/liter in the suicide groups. We concluded that management of acetaminophen toxicity can be optimized by early identification, obtaining a complete drug screen, starting N-acetylcysteine early or whenever toxic acetaminophen levels or elevated transaminases are identified, and referring patients with acetaminophen toxicity to a liver center.

Original languageEnglish (US)
Pages (from-to)1553-1558
Number of pages6
JournalDigestive Diseases and Sciences
Volume45
Issue number8
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Acetaminophen
Acetylcysteine
Transaminases
Suicide
Pregnancy in Adolescence
Poisons
Alcoholism
Substance-Related Disorders
Psychiatry
Length of Stay
Psychology
Liver
Pharmaceutical Preparations

Keywords

  • Acetaminophen
  • Alcohol
  • Liver
  • Overdose
  • Poisoning

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Acetaminophen hepatotoxicity. / Broughan, T. A.; Soloway, R. D.

In: Digestive Diseases and Sciences, Vol. 45, No. 8, 2000, p. 1553-1558.

Research output: Contribution to journalArticle

Broughan, TA & Soloway, RD 2000, 'Acetaminophen hepatotoxicity', Digestive Diseases and Sciences, vol. 45, no. 8, pp. 1553-1558. https://doi.org/10.1023/A:1005508910222
Broughan, T. A. ; Soloway, R. D. / Acetaminophen hepatotoxicity. In: Digestive Diseases and Sciences. 2000 ; Vol. 45, No. 8. pp. 1553-1558.
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