Acetaminophen metabolism in subjects fed charcoal-broiled beef

Karl Anderson, Jill Schneider, Eugene J. Pantuck, Carol B. Pantuck, Gilbert H. Mudge, Richard M. Welch, Allan H. Conney, Attallah Kappas

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effects of consumption of charcoal-broiled beef on the metabolism of acetaminophen by conjugation were determined in nine normal subjects. We had reported that beef prepared in this manner accelerates the oxidative metabolism of drugs, including the oxidation of phenacetin to N-acetyl-p-aminophenol (acetaminophen). In nine normal subjects, a control diet was followed by a charcoal-broiled beef diet, which was followed by the control diet. The charcoal-broiled beef had little or no effect on the plasma-level profile of acetaminophen, acetaminophen glucuronide and acetaminophen sulfate, or on the urinary excretion of acetaminophen, acetaminophen glucuronide, acetaminophen sulfate, 3-methoxy-acetaminophen, or the cysteine and mercapturic acid conjugates of acetaminophen. Results indicate that the enzyme systems that conjugate acetaminophen in man are subject to little or no influence by charcoal-broiled beef. Therefore dietary factors that increase drug oxidations cannot be assumed to have a similar effect on drug conjugation.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume34
Issue number3
StatePublished - Sep 1983
Externally publishedYes

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Charcoal
Acetaminophen
Glucuronides
Diet
Sulfates
Red Meat
Pharmaceutical Preparations
Phenacetin
Acetylcysteine
Cysteine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Anderson, K., Schneider, J., Pantuck, E. J., Pantuck, C. B., Mudge, G. H., Welch, R. M., ... Kappas, A. (1983). Acetaminophen metabolism in subjects fed charcoal-broiled beef. Clinical Pharmacology and Therapeutics, 34(3), 369-374.

Acetaminophen metabolism in subjects fed charcoal-broiled beef. / Anderson, Karl; Schneider, Jill; Pantuck, Eugene J.; Pantuck, Carol B.; Mudge, Gilbert H.; Welch, Richard M.; Conney, Allan H.; Kappas, Attallah.

In: Clinical Pharmacology and Therapeutics, Vol. 34, No. 3, 09.1983, p. 369-374.

Research output: Contribution to journalArticle

Anderson, K, Schneider, J, Pantuck, EJ, Pantuck, CB, Mudge, GH, Welch, RM, Conney, AH & Kappas, A 1983, 'Acetaminophen metabolism in subjects fed charcoal-broiled beef', Clinical Pharmacology and Therapeutics, vol. 34, no. 3, pp. 369-374.
Anderson K, Schneider J, Pantuck EJ, Pantuck CB, Mudge GH, Welch RM et al. Acetaminophen metabolism in subjects fed charcoal-broiled beef. Clinical Pharmacology and Therapeutics. 1983 Sep;34(3):369-374.
Anderson, Karl ; Schneider, Jill ; Pantuck, Eugene J. ; Pantuck, Carol B. ; Mudge, Gilbert H. ; Welch, Richard M. ; Conney, Allan H. ; Kappas, Attallah. / Acetaminophen metabolism in subjects fed charcoal-broiled beef. In: Clinical Pharmacology and Therapeutics. 1983 ; Vol. 34, No. 3. pp. 369-374.
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