Acid-responsive nanospheres from an asparagine-derived amphiphile

Adelphe M. Mfuh, Mathew P.D. Mahindaratne, Audrey E. Yñigez-Gutierrez, Juan R. Ramos Dominguez, Jefferson T. Bedell, Carlos D. Garcia, George R. Negrete

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

Original languageEnglish (US)
Pages (from-to)8585-8590
Number of pages6
JournalRSC Advances
Volume5
Issue number12
DOIs
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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