Acid-responsive nanospheres from an asparagine-derived amphiphile

Adelphe M. Mfuh; Mathew P.D. Mahindaratne; Audrey E. Yñigez-Gutierrez; Juan R. Ramos Dominguez; Jefferson T. Bedell; Carlos D. Garcia; George R. Negrete

doi:10.1039/c4ra11884g

Acid-responsive nanospheres from an asparagine-derived amphiphile

Adelphe M. Mfuh
, Mathew P.D. Mahindaratne
, Audrey E. Yñigez-Gutierrez
, Juan R. Ramos Dominguez
, Jefferson T. Bedell
, Carlos D. Garcia
, George R. Negrete

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

Original language	English (US)
Pages (from-to)	8585-8590
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/c4ra11884g
State	Published - 2015
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c4ra11884g

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title = "Acid-responsive nanospheres from an asparagine-derived amphiphile",

abstract = "We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol\%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.",

author = "Mfuh, \{Adelphe M.\} and Mahindaratne, \{Mathew P.D.\} and Y{\~n}igez-Gutierrez, \{Audrey E.\} and \{Ramos Dominguez\}, \{Juan R.\} and Bedell, \{Jefferson T.\} and Garcia, \{Carlos D.\} and Negrete, \{George R.\}",

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AU - Mfuh, Adelphe M.

AU - Mahindaratne, Mathew P.D.

AU - Yñigez-Gutierrez, Audrey E.

AU - Ramos Dominguez, Juan R.

AU - Bedell, Jefferson T.

AU - Garcia, Carlos D.

AU - Negrete, George R.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015

Y1 - 2015

N2 - We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

AB - We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

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UR - https://www.scopus.com/pages/publications/84921284423#tab=citedBy

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DO - 10.1039/c4ra11884g

M3 - Article

AN - SCOPUS:84921284423

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EP - 8590

JO - RSC Advances

JF - RSC Advances

IS - 12

ER -

Acid-responsive nanospheres from an asparagine-derived amphiphile

Abstract

ASJC Scopus subject areas

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