Acoustic brainstem nuclei express Fos after flurothyl-induce generalized seizures in rats

D. C. Silveira; S. C. Schachter; D. L. Schomer

doi:10.1016/S0920-1211(98)00089-8

Acoustic brainstem nuclei express Fos after flurothyl-induce generalized seizures in rats

D. C. Silveira, S. C. Schachter, D. L. Schomer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The inferior colliculus (IC) plays a key role in modulating audiogenic seizures (AS) in rats. We investigated whether acoustic brainstem nuclei express Fos-like immunoreactivity (FLI) after flurothyl-induced generalized Seizures in rats. Compared to controls, experimental animals showed significantly (P < 0.05) more FLI in the dorsal and external cortex of the IC, as well as in the medial part of the medial geniculate body (MGB), perigeniculate area, and dorsal cochlear nucleus. No significant increase of FLI was observed in the central nucleus of the IC, ventral and dorsal parts of the MGB, dorsal nucleus of the lateral lemniscus, or ventral cochlear nucleus. Because, this pattern of FLI closely resembles that observed after AS in previous studies, these results suggest that Fos expression in acoustic brainstem nuclei is not specific for AS.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Epilepsy Research
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/S0920-1211(98)00089-8
State	Published - Mar 1999
Externally published	Yes

Keywords

Brainstem
Flurothyl
Fos
Inferior colliculus
Seizures

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/S0920-1211(98)00089-8

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title = "Acoustic brainstem nuclei express Fos after flurothyl-induce generalized seizures in rats",

abstract = "The inferior colliculus (IC) plays a key role in modulating audiogenic seizures (AS) in rats. We investigated whether acoustic brainstem nuclei express Fos-like immunoreactivity (FLI) after flurothyl-induced generalized Seizures in rats. Compared to controls, experimental animals showed significantly (P < 0.05) more FLI in the dorsal and external cortex of the IC, as well as in the medial part of the medial geniculate body (MGB), perigeniculate area, and dorsal cochlear nucleus. No significant increase of FLI was observed in the central nucleus of the IC, ventral and dorsal parts of the MGB, dorsal nucleus of the lateral lemniscus, or ventral cochlear nucleus. Because, this pattern of FLI closely resembles that observed after AS in previous studies, these results suggest that Fos expression in acoustic brainstem nuclei is not specific for AS.",

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AU - Silveira, D. C.

AU - Schachter, S. C.

AU - Schomer, D. L.

PY - 1999/3

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N2 - The inferior colliculus (IC) plays a key role in modulating audiogenic seizures (AS) in rats. We investigated whether acoustic brainstem nuclei express Fos-like immunoreactivity (FLI) after flurothyl-induced generalized Seizures in rats. Compared to controls, experimental animals showed significantly (P < 0.05) more FLI in the dorsal and external cortex of the IC, as well as in the medial part of the medial geniculate body (MGB), perigeniculate area, and dorsal cochlear nucleus. No significant increase of FLI was observed in the central nucleus of the IC, ventral and dorsal parts of the MGB, dorsal nucleus of the lateral lemniscus, or ventral cochlear nucleus. Because, this pattern of FLI closely resembles that observed after AS in previous studies, these results suggest that Fos expression in acoustic brainstem nuclei is not specific for AS.

AB - The inferior colliculus (IC) plays a key role in modulating audiogenic seizures (AS) in rats. We investigated whether acoustic brainstem nuclei express Fos-like immunoreactivity (FLI) after flurothyl-induced generalized Seizures in rats. Compared to controls, experimental animals showed significantly (P < 0.05) more FLI in the dorsal and external cortex of the IC, as well as in the medial part of the medial geniculate body (MGB), perigeniculate area, and dorsal cochlear nucleus. No significant increase of FLI was observed in the central nucleus of the IC, ventral and dorsal parts of the MGB, dorsal nucleus of the lateral lemniscus, or ventral cochlear nucleus. Because, this pattern of FLI closely resembles that observed after AS in previous studies, these results suggest that Fos expression in acoustic brainstem nuclei is not specific for AS.

KW - Brainstem

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KW - Fos

KW - Inferior colliculus

KW - Seizures

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Acoustic brainstem nuclei express Fos after flurothyl-induce generalized seizures in rats

Abstract

Keywords

ASJC Scopus subject areas

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