Acrylonitrile and tissue glutathione: Differential effect of acute and chronic interactions

S. Szabo, K. A. Bailey, P. J. Boor, R. J. Jaeger

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Acrylonitrile (vinyl cyanide) is a reactive chemical extensively used in the synthesis of buna rubber and polymerized plastics (e.g., disposable bottles). A single dose of the chemical causes adrenal hemorrhage, while chronic ingesting results in adrenocortical hypofunction. Present acute experiments in rats show a rapid time- and dose-dependent decrease in reduced glutathione (GSH) in the liver, lung, kidney and adrenal. The diminution of cerebral GSH concentration is gradual and seems to correlate with the occurrence of mortality in acute experiments. Chronic ingestion of acrylonitrile in drinking water results in a dose dependent increase of hepatic GSH concentration, similar to that caused by chemical carcinogens.

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume79
Issue number1
DOIs
StatePublished - Nov 7 1977

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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