TY - JOUR
T1 - Acrylonitrile and tissue glutathione
T2 - Differential effect of acute and chronic interactions
AU - Szabo, S.
AU - Bailey, K. A.
AU - Boor, P. J.
AU - Jaeger, R. J.
PY - 1977/11/7
Y1 - 1977/11/7
N2 - Acrylonitrile (vinyl cyanide) is a reactive chemical extensively used in the synthesis of buna rubber and polymerized plastics (e.g., disposable bottles). A single dose of the chemical causes adrenal hemorrhage, while chronic ingesting results in adrenocortical hypofunction. Present acute experiments in rats show a rapid time- and dose-dependent decrease in reduced glutathione (GSH) in the liver, lung, kidney and adrenal. The diminution of cerebral GSH concentration is gradual and seems to correlate with the occurrence of mortality in acute experiments. Chronic ingestion of acrylonitrile in drinking water results in a dose dependent increase of hepatic GSH concentration, similar to that caused by chemical carcinogens.
AB - Acrylonitrile (vinyl cyanide) is a reactive chemical extensively used in the synthesis of buna rubber and polymerized plastics (e.g., disposable bottles). A single dose of the chemical causes adrenal hemorrhage, while chronic ingesting results in adrenocortical hypofunction. Present acute experiments in rats show a rapid time- and dose-dependent decrease in reduced glutathione (GSH) in the liver, lung, kidney and adrenal. The diminution of cerebral GSH concentration is gradual and seems to correlate with the occurrence of mortality in acute experiments. Chronic ingestion of acrylonitrile in drinking water results in a dose dependent increase of hepatic GSH concentration, similar to that caused by chemical carcinogens.
UR - http://www.scopus.com/inward/record.url?scp=0017762498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017762498&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(77)90056-0
DO - 10.1016/0006-291X(77)90056-0
M3 - Article
C2 - 921805
AN - SCOPUS:0017762498
SN - 0006-291X
VL - 79
SP - 32
EP - 37
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -