ACTH increases adrenal medullary PNMT activity in neonatal rats

Tapan K. Banerji, Gerald Callas, Walter Meyer, Amir Rassoli

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Abstract

Levels of plasma corticosterone and the activities of adrenomedullary dopamine-β-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were measured in the 7-day-old rat following the administration of adrenocorticotropic hormone (ACTH) for 7 consecutive days beginning with day 1. ACTH led to significant adrenal hypertrophy and a concomitant elevation (10 to 15 fold) of plasma corticosterone concentration. Whereas DBH activity remained unchanged, adrenal PNMT activity was increased significantly following ACTH-induced elevation of plasma corticosterone levels. These results indicate that the pituitary-adreno-cortical-adrenomedullary axis is functional in the neonatal rat. Furthermore, since the transsynaptic control mechanisms are known to be non-functional or immature in the 7-day-old rat, our data suggest that neonatal rat adrenal catecholamine biosynthesis may be largely controlled by the pituitary-adrenocortical axis via glucocorticoids.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalLife Sciences
Volume38
Issue number4
DOIs
StatePublished - Jan 27 1986

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Banerji, T. K., Callas, G., Meyer, W., & Rassoli, A. (1986). ACTH increases adrenal medullary PNMT activity in neonatal rats. Life Sciences, 38(4), 343-349. https://doi.org/10.1016/0024-3205(86)90081-0