Abstract
The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (μ, morphine; κ, dynorphin; δ, methionine enkephalinamide; σ, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally inhibitory, although excitatory or mixed effects were sometimes seen, especially with morphine and dynorphin. Drug effects could change, depending on the position of the iontophoretic electrode array or on the current employed. Naloxone sometimes antagonized the action of the opiate drugs used, but naloxone did not seem to be a drug suited for iontophoretic application. A number of explanations are discussed to explain the variable actions of the opiate drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2509-2520 |
| Number of pages | 12 |
| Journal | Journal of Neuroscience |
| Volume | 6 |
| Issue number | 9 |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Actions of opioids on primate spinothalamic tract neurons. / Willcockson, W. S.; Kim, J.; Shin, H. K.; Chung, Jin; Willis, W. D.
In: Journal of Neuroscience, Vol. 6, No. 9, 1986, p. 2509-2520.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Actions of opioids on primate spinothalamic tract neurons
AU - Willcockson, W. S.
AU - Kim, J.
AU - Shin, H. K.
AU - Chung, Jin
AU - Willis, W. D.
PY - 1986
Y1 - 1986
N2 - The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (μ, morphine; κ, dynorphin; δ, methionine enkephalinamide; σ, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally inhibitory, although excitatory or mixed effects were sometimes seen, especially with morphine and dynorphin. Drug effects could change, depending on the position of the iontophoretic electrode array or on the current employed. Naloxone sometimes antagonized the action of the opiate drugs used, but naloxone did not seem to be a drug suited for iontophoretic application. A number of explanations are discussed to explain the variable actions of the opiate drugs.
AB - The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (μ, morphine; κ, dynorphin; δ, methionine enkephalinamide; σ, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally inhibitory, although excitatory or mixed effects were sometimes seen, especially with morphine and dynorphin. Drug effects could change, depending on the position of the iontophoretic electrode array or on the current employed. Naloxone sometimes antagonized the action of the opiate drugs used, but naloxone did not seem to be a drug suited for iontophoretic application. A number of explanations are discussed to explain the variable actions of the opiate drugs.
UR - http://www.scopus.com/inward/record.url?scp=0022884848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022884848&partnerID=8YFLogxK
M3 - Article
C2 - 2875139
AN - SCOPUS:0022884848
VL - 6
SP - 2509
EP - 2520
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 9
ER -