Activation of hedgehog signaling is not a frequent event in ovarian cancers

Ling Yang, Jing He, Shuhong Huang, Xiaoli Zhang, Yuehong Bian, Nonggao He, Hongwei Zhang, Jingwu Xie

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression by it in-situ it hybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors.

Original languageEnglish (US)
Article number112
JournalMolecular Cancer
Volume8
DOIs
StatePublished - Nov 27 2009

Fingerprint

Ovarian Neoplasms
Neoplasms
Gene Expression
Phase II Clinical Trials
In Situ Hybridization
Real-Time Polymerase Chain Reaction
Homeostasis
Immunohistochemistry
Clinical Trials
Drug Therapy
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

Cite this

Activation of hedgehog signaling is not a frequent event in ovarian cancers. / Yang, Ling; He, Jing; Huang, Shuhong; Zhang, Xiaoli; Bian, Yuehong; He, Nonggao; Zhang, Hongwei; Xie, Jingwu.

In: Molecular Cancer, Vol. 8, 112, 27.11.2009.

Research output: Contribution to journalArticle

Yang, Ling ; He, Jing ; Huang, Shuhong ; Zhang, Xiaoli ; Bian, Yuehong ; He, Nonggao ; Zhang, Hongwei ; Xie, Jingwu. / Activation of hedgehog signaling is not a frequent event in ovarian cancers. In: Molecular Cancer. 2009 ; Vol. 8.
@article{80f7d88bd2e84fe4b1faaa59045a87c0,
title = "Activation of hedgehog signaling is not a frequent event in ovarian cancers",
abstract = "The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30{\%} of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression by it in-situ it hybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors.",
author = "Ling Yang and Jing He and Shuhong Huang and Xiaoli Zhang and Yuehong Bian and Nonggao He and Hongwei Zhang and Jingwu Xie",
year = "2009",
month = "11",
day = "27",
doi = "10.1186/1476-4598-8-112",
language = "English (US)",
volume = "8",
journal = "Molecular Cancer",
issn = "1476-4598",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Activation of hedgehog signaling is not a frequent event in ovarian cancers

AU - Yang, Ling

AU - He, Jing

AU - Huang, Shuhong

AU - Zhang, Xiaoli

AU - Bian, Yuehong

AU - He, Nonggao

AU - Zhang, Hongwei

AU - Xie, Jingwu

PY - 2009/11/27

Y1 - 2009/11/27

N2 - The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression by it in-situ it hybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors.

AB - The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression by it in-situ it hybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=71549129295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71549129295&partnerID=8YFLogxK

U2 - 10.1186/1476-4598-8-112

DO - 10.1186/1476-4598-8-112

M3 - Article

C2 - 19943941

AN - SCOPUS:71549129295

VL - 8

JO - Molecular Cancer

JF - Molecular Cancer

SN - 1476-4598

M1 - 112

ER -