Abstract
An established cell line transformed by herpes simplex virus type 2 and derived from hamster tumors contained herpesvirus specific intracellular and surface antigens in some 2-5% of cells but did not produce infectious virus. Arginine deprivation resulted in induction of virus specific intracellular and surface antigens in 70-75% and about 40% of cells respectively, while no infectious virus was induced. After treatment of the cultures with IUDR, 70-75% of the cells showed virus specific intracellular fluorescence and 45-50% exhibited cell membrane fluorescence, and infectious virus could be detected. Induction by IUDR could be inhibited by simultaneous treatment of cultures with cytosine arabinoside.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 62-69 |
| Number of pages | 8 |
| Journal | Archiv für die gesamte Virusforschung |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1974 |
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Genetics