Activation of herpes specific antigens and infectious virus in a hamster cell line transformed by HSV-2

L. Váczi, I. Boldogh, Eva Gönczöl

Research output: Contribution to journalArticle

4 Scopus citations


An established cell line transformed by herpes simplex virus type 2 and derived from hamster tumors contained herpesvirus specific intracellular and surface antigens in some 2-5% of cells but did not produce infectious virus. Arginine deprivation resulted in induction of virus specific intracellular and surface antigens in 70-75% and about 40% of cells respectively, while no infectious virus was induced. After treatment of the cultures with IUDR, 70-75% of the cells showed virus specific intracellular fluorescence and 45-50% exhibited cell membrane fluorescence, and infectious virus could be detected. Induction by IUDR could be inhibited by simultaneous treatment of cultures with cytosine arabinoside.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalArchiv für die gesamte Virusforschung
Issue number1
StatePublished - Mar 1974


ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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