Activation of herpes specific antigens and infectious virus in a hamster cell line transformed by HSV-2

L. Váczi, I. Boldogh, Eva Gönczöl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An established cell line transformed by herpes simplex virus type 2 and derived from hamster tumors contained herpesvirus specific intracellular and surface antigens in some 2-5% of cells but did not produce infectious virus. Arginine deprivation resulted in induction of virus specific intracellular and surface antigens in 70-75% and about 40% of cells respectively, while no infectious virus was induced. After treatment of the cultures with IUDR, 70-75% of the cells showed virus specific intracellular fluorescence and 45-50% exhibited cell membrane fluorescence, and infectious virus could be detected. Induction by IUDR could be inhibited by simultaneous treatment of cultures with cytosine arabinoside.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalArchiv für die gesamte Virusforschung
Volume44
Issue number1
DOIs
StatePublished - Mar 1974

Fingerprint

Transformed Cell Line
Human Herpesvirus 2
Cricetinae
Viruses
Antigens
Surface Antigens
Fluorescence
Virus Activation
Herpesviridae
Cytarabine
Arginine
Cell Membrane
Neoplasms

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

Cite this

Activation of herpes specific antigens and infectious virus in a hamster cell line transformed by HSV-2. / Váczi, L.; Boldogh, I.; Gönczöl, Eva.

In: Archiv für die gesamte Virusforschung, Vol. 44, No. 1, 03.1974, p. 62-69.

Research output: Contribution to journalArticle

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