Activation of proto-oncogenes: An immediate early event in human cytomegalovirus infection

Istran Boldogh, Sazaly Abubakar, Thomas Albrecht

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

A rapid increase in the RNA levels of the proto-oncogenes c-fos, c-jun, and c-myc was detected after human cytomegalovirus infection. Neither inactivation of viral infectivity with ultraviolet irradiation (with or without psoralen), nor inhibition of translation with cycloheximide or anisomycin adversely affected the enhanced expression of protooncogenes, even though these treatments substantially reduced or eliminated the detection of immediate early viral antigens. The increase in the RNA levels of the proto-oncogenes was prevented in the presence of α-amanitin or actinomycin D. Thus, expression of these oncogenes appears to be induced by events occurring before the onset of viral protein synthesis, perhaps by the interaction of viral particles with the cell surface.

Original languageEnglish (US)
Pages (from-to)561-564
Number of pages4
JournalScience
Volume247
Issue number4942
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • General

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