Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro

D. W. Powell, H. J. Binder, P. F. Curran

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Abstract

Purified cholera toxin added to the mucosal solution of rabbit ileum in vitro caused changes in ion fluxes and electrical properties after a 50 to 60 min lag period. Potential difference and short circuit current increased and tissue conductance decreased. In Ringer solution containing HCO3, the toxin caused net secretion of both Na and Cl. In HCO3 free solution, the toxin reduced net Na transport to zero and caused Cl secretion. No toxic effects were observed on Na fluxes in HCO3 Cl free solution or on Cl fluxes in Na free solution. The changes in net electrolyte fluxes are most easily explained by postulating that cholera toxin stimulates an electrically neutral process that transports NaCl and/or NaCHO3 from serosa to mucosa.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages781-787
Number of pages7
Volume225
Edition4
StatePublished - 1973
Externally publishedYes

Fingerprint

Cholera Toxin
Ileum
Electrolytes
Rabbits
Serous Membrane
Poisons
Mucous Membrane
Ions
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Powell, D. W., Binder, H. J., & Curran, P. F. (1973). Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. In American Journal of Physiology (4 ed., Vol. 225, pp. 781-787)

Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. / Powell, D. W.; Binder, H. J.; Curran, P. F.

American Journal of Physiology. Vol. 225 4. ed. 1973. p. 781-787.

Research output: Chapter in Book/Report/Conference proceedingChapter

Powell, DW, Binder, HJ & Curran, PF 1973, Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. in American Journal of Physiology. 4 edn, vol. 225, pp. 781-787.
Powell DW, Binder HJ, Curran PF. Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. In American Journal of Physiology. 4 ed. Vol. 225. 1973. p. 781-787
Powell, D. W. ; Binder, H. J. ; Curran, P. F. / Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. American Journal of Physiology. Vol. 225 4. ed. 1973. pp. 781-787
@inbook{3b4448eee65043678ce3afefae528d35,
title = "Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro",
abstract = "Purified cholera toxin added to the mucosal solution of rabbit ileum in vitro caused changes in ion fluxes and electrical properties after a 50 to 60 min lag period. Potential difference and short circuit current increased and tissue conductance decreased. In Ringer solution containing HCO3, the toxin caused net secretion of both Na and Cl. In HCO3 free solution, the toxin reduced net Na transport to zero and caused Cl secretion. No toxic effects were observed on Na fluxes in HCO3 Cl free solution or on Cl fluxes in Na free solution. The changes in net electrolyte fluxes are most easily explained by postulating that cholera toxin stimulates an electrically neutral process that transports NaCl and/or NaCHO3 from serosa to mucosa.",
author = "Powell, {D. W.} and Binder, {H. J.} and Curran, {P. F.}",
year = "1973",
language = "English (US)",
volume = "225",
pages = "781--787",
booktitle = "American Journal of Physiology",
edition = "4",

}

TY - CHAP

T1 - Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro

AU - Powell, D. W.

AU - Binder, H. J.

AU - Curran, P. F.

PY - 1973

Y1 - 1973

N2 - Purified cholera toxin added to the mucosal solution of rabbit ileum in vitro caused changes in ion fluxes and electrical properties after a 50 to 60 min lag period. Potential difference and short circuit current increased and tissue conductance decreased. In Ringer solution containing HCO3, the toxin caused net secretion of both Na and Cl. In HCO3 free solution, the toxin reduced net Na transport to zero and caused Cl secretion. No toxic effects were observed on Na fluxes in HCO3 Cl free solution or on Cl fluxes in Na free solution. The changes in net electrolyte fluxes are most easily explained by postulating that cholera toxin stimulates an electrically neutral process that transports NaCl and/or NaCHO3 from serosa to mucosa.

AB - Purified cholera toxin added to the mucosal solution of rabbit ileum in vitro caused changes in ion fluxes and electrical properties after a 50 to 60 min lag period. Potential difference and short circuit current increased and tissue conductance decreased. In Ringer solution containing HCO3, the toxin caused net secretion of both Na and Cl. In HCO3 free solution, the toxin reduced net Na transport to zero and caused Cl secretion. No toxic effects were observed on Na fluxes in HCO3 Cl free solution or on Cl fluxes in Na free solution. The changes in net electrolyte fluxes are most easily explained by postulating that cholera toxin stimulates an electrically neutral process that transports NaCl and/or NaCHO3 from serosa to mucosa.

UR - http://www.scopus.com/inward/record.url?scp=0015904931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015904931&partnerID=8YFLogxK

M3 - Chapter

VL - 225

SP - 781

EP - 787

BT - American Journal of Physiology

ER -