Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661

Keyphrases

• Hepatitis C Virus 100%
• Activation Mechanism 100%
• Metabolic Activation 100%
• NS5B 100%
• Pronucleotides 100%
• Amino Acids 75%
• Replicon 50%
• Genotype 1 50%
• Genotype 2a 50%
• Hydrolysis 50%
• Replicon-RNA 50%
• 5′-monophosphate 50%
• Fluoro 50%
• Acid Alteration 50%
• Diphosphate 50%
• S282T 50%
• Metabolism 25%
• Phosphate 25%
• Mitochondrial Toxicity 25%
• Virus Replication 25%
• Phosphorylation 25%
• Cell Toxicity 25%
• Infectious Virus 25%
• Phosphorus 25%
• Adenosine Deaminase 25%
• Triphosphate 25%
• Bone Marrow Cells 25%
• Nucleosides 25%
• Highly Active 25%
• Carboxyl 25%
• Carboxylesterase 1 (CES1) 25%
• 5-bisphosphate 25%
• Esters 25%
• Carboxyl Group 25%
• Decreased Susceptibility 25%
• Guanine Base 25%
• Genotype 1b 25%
• No Toxicity 25%
• Nucleophilic Attack 25%
• Clear Cell 25%
• Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) 25%
• Guanylate Kinase 25%
• Methoxyl Group 25%
• Monophosphate 25%
• Cathepsin 25%
• Histidine Triad nucleotide-binding Protein 1 25%
• Phosphoramidate Prodrug 25%
• HCV Replication 25%
• HCV Replicon 25%
• Nucleoside Diphosphate Kinase 25%
• Replicon Assay 25%

Biochemistry, Genetics and Molecular Biology

• Hepatitis C Virus 100%
• Replicon 100%
• Metabolic Activation 100%
• NS5B 80%
• Amino Acids 60%
• Enzymatic Hydrolysis 40%
• Nucleoside 40%
• RNA 40%
• Genotyping 40%
• Synapsin I 40%
• Pyrophosphate 40%
• Metabolic Pathway 20%
• Binding Protein 20%
• Metabolite 20%
• Virus Replication 20%
• Wild Type 20%
• Enzyme 20%
• RNA Replication 20%
• Virus Infectivity 20%
• Adenosine Deaminase 20%
• Nucleophilicity 20%
• Hepatitis C Virus Subtype 1b 20%
• Hepatitis C Virus Subtype 2a 20%
• Rebound 20%
• Hepatitis C Virus Subtype 1a 20%
• Carboxylesterase 1 20%
• Guanylate Kinase 20%
• Carboxypeptidase C 20%
• Nucleoside-Diphosphate Kinase 20%
• Hematopoietic Cell 20%
• Guanine 20%
• Histidine 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Hepatitis C Virus 100%
• Synapsin I 66%
• Nucleoside 66%
• Pyrophosphate 66%
• Mitochondrial Toxicity 33%
• Guanine 33%
• Base 33%
• Elimination 33%
• Prodrug 33%
• Virus Infectivity 33%
• Histidine 33%
• Carboxylesterase 33%
• Adenosine Deaminase 33%
• Carboxyl Group 33%
• Carboxypeptidase C 33%
• Hepatitis C Virus Subtype 1a 33%
• Nucleoside Diphosphate Kinase 33%
• Guanylate Kinase 33%
• Hepatitis C Virus Subtype 2a 33%
• Nucleotide Binding Protein 33%
• Hepatitis C Virus Subtype 1b 33%
• Phenol 33%