Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Jianyong Chen, Sin Park Chang, Shao Jun Tang

    Research output: Contribution to journalArticlepeer-review

    266 Scopus citations

    Abstract

    Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-D-aspartate receptor-dependent synaptic Wnt3a release, nuclear β-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.

    Original languageEnglish (US)
    Pages (from-to)11910-11916
    Number of pages7
    JournalJournal of Biological Chemistry
    Volume281
    Issue number17
    DOIs
    StatePublished - Apr 28 2006

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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