Acupuncture points can be identified as cutaneous neurogenic inflammatory spots

Do Hee Kim, Yeonhee Ryu, Dae Hyun Hahm, Boo Yong Sohn, Insop Shim, O. Sang Kwon, Suchan Chang, Young Seob Gwak, Min Sun Kim, Jae Hyo Kim, Bong Hyo Lee, Eun Young Jang, Rongjie Zhao, Jin Chung, Chae Ha Yang, Hee Young Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, which is likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via the endogenous opioid system. Our results suggest that acupoints associated with internal organs may be identical to neurogenic inflammatory spots on the skin, which are produced by activation of somatic afferents in abnormal conditions of visceral organs.

Original languageEnglish (US)
Article number15195
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Acupuncture Points
Skin
Neurogenic Inflammation
Opioid Analgesics
Visceral Afferents
Therapeutic Uses
Acupuncture
Colitis
Nerve Fibers
Hypersensitivity
Hypertension

ASJC Scopus subject areas

  • General

Cite this

Kim, D. H., Ryu, Y., Hahm, D. H., Sohn, B. Y., Shim, I., Kwon, O. S., ... Kim, H. Y. (2017). Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. Scientific Reports, 7(1), [15195]. https://doi.org/10.1038/s41598-017-14359-z

Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. / Kim, Do Hee; Ryu, Yeonhee; Hahm, Dae Hyun; Sohn, Boo Yong; Shim, Insop; Kwon, O. Sang; Chang, Suchan; Gwak, Young Seob; Kim, Min Sun; Kim, Jae Hyo; Lee, Bong Hyo; Jang, Eun Young; Zhao, Rongjie; Chung, Jin; Yang, Chae Ha; Kim, Hee Young.

In: Scientific Reports, Vol. 7, No. 1, 15195, 01.12.2017.

Research output: Contribution to journalArticle

Kim, DH, Ryu, Y, Hahm, DH, Sohn, BY, Shim, I, Kwon, OS, Chang, S, Gwak, YS, Kim, MS, Kim, JH, Lee, BH, Jang, EY, Zhao, R, Chung, J, Yang, CH & Kim, HY 2017, 'Acupuncture points can be identified as cutaneous neurogenic inflammatory spots', Scientific Reports, vol. 7, no. 1, 15195. https://doi.org/10.1038/s41598-017-14359-z
Kim, Do Hee ; Ryu, Yeonhee ; Hahm, Dae Hyun ; Sohn, Boo Yong ; Shim, Insop ; Kwon, O. Sang ; Chang, Suchan ; Gwak, Young Seob ; Kim, Min Sun ; Kim, Jae Hyo ; Lee, Bong Hyo ; Jang, Eun Young ; Zhao, Rongjie ; Chung, Jin ; Yang, Chae Ha ; Kim, Hee Young. / Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
@article{a5615683733c4b03bdb0c8eb24d88e5a,
title = "Acupuncture points can be identified as cutaneous neurogenic inflammatory spots",
abstract = "Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, which is likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via the endogenous opioid system. Our results suggest that acupoints associated with internal organs may be identical to neurogenic inflammatory spots on the skin, which are produced by activation of somatic afferents in abnormal conditions of visceral organs.",
author = "Kim, {Do Hee} and Yeonhee Ryu and Hahm, {Dae Hyun} and Sohn, {Boo Yong} and Insop Shim and Kwon, {O. Sang} and Suchan Chang and Gwak, {Young Seob} and Kim, {Min Sun} and Kim, {Jae Hyo} and Lee, {Bong Hyo} and Jang, {Eun Young} and Rongjie Zhao and Jin Chung and Yang, {Chae Ha} and Kim, {Hee Young}",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-14359-z",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Acupuncture points can be identified as cutaneous neurogenic inflammatory spots

AU - Kim, Do Hee

AU - Ryu, Yeonhee

AU - Hahm, Dae Hyun

AU - Sohn, Boo Yong

AU - Shim, Insop

AU - Kwon, O. Sang

AU - Chang, Suchan

AU - Gwak, Young Seob

AU - Kim, Min Sun

AU - Kim, Jae Hyo

AU - Lee, Bong Hyo

AU - Jang, Eun Young

AU - Zhao, Rongjie

AU - Chung, Jin

AU - Yang, Chae Ha

AU - Kim, Hee Young

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, which is likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via the endogenous opioid system. Our results suggest that acupoints associated with internal organs may be identical to neurogenic inflammatory spots on the skin, which are produced by activation of somatic afferents in abnormal conditions of visceral organs.

AB - Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by the activation of small diameter afferent nerve fibres and therapeutic effects on the associated visceral organs, which is likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via the endogenous opioid system. Our results suggest that acupoints associated with internal organs may be identical to neurogenic inflammatory spots on the skin, which are produced by activation of somatic afferents in abnormal conditions of visceral organs.

UR - http://www.scopus.com/inward/record.url?scp=85033674210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033674210&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-14359-z

DO - 10.1038/s41598-017-14359-z

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15195

ER -