Acute and chronic phencyclidine administration: Effects on the conversion of3H-tryptophan to3H-serotonin in rat forebrain

K. M. Johnson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Acute administration of phencyclidine hydrochloride (PCP) resulted in a dose-responsive decrease in the conversion of3H-tryptophan to3H-serotonin (3H-5-HT) in rat forebrain. Subsequent experiments measured the effect of a subthreshold dose of PCP (4 mg/kg) daily for one, seven, or fourteen days on this index of 5-HT turnover. Although single administration again had no effect at this dose, repeated administration for seven days resulted in a 37% decrease in 5-HT turnover. However, after fourteen days of administration this index was not significantly different from saline controls. The possible significance of these findings are discussed in relation to reported alterations in PCP-induced behaviors observed with chronic administration.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalJournal of Neural Transmission
Volume53
Issue number2-3
DOIs
StatePublished - Jun 1 1982

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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