Abstract
Hypertensive disorders in pregnancy constitute one of the most frequent medical complications during gestation. Unfortunately, maternal and perinatal mortality remains significant worldwide in this population. Not infrequently, patients with severe preeclampsia will need parenteral agents to achieve rapid blood pressure control to avoid end-organ damage. During the last decades, new antihypertensive medications have become available for management of hypertensive crisis. One of these agents is the calcium channel blocker nicardipine. Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients. Minimal data exist in the literature regarding the use of this medicine during pregnancy. The purpose of this article is to review the pharmacological properties of nicardipine, the available literature regarding its use during pregnancy, and potential interactions with other medicines used commonly in preeclampsia, as well as potential side effects directly affecting the peripartum period.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-499 |
| Number of pages | 5 |
| Journal | American Journal of Perinatology |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 2009 |
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Keywords
- Hypertension
- Nicardipine
- Preeclampsia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
Acute antihypertensive therapy in pregnancy-induced hypertension : Is nicardipine the answer? / Vadhera, Rakesh; Pacheco, Luis; Hankins, Gary.
In: American Journal of Perinatology, Vol. 26, No. 7, 08.2009, p. 495-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute antihypertensive therapy in pregnancy-induced hypertension
T2 - Is nicardipine the answer?
AU - Vadhera, Rakesh
AU - Pacheco, Luis
AU - Hankins, Gary
PY - 2009/8
Y1 - 2009/8
N2 - Hypertensive disorders in pregnancy constitute one of the most frequent medical complications during gestation. Unfortunately, maternal and perinatal mortality remains significant worldwide in this population. Not infrequently, patients with severe preeclampsia will need parenteral agents to achieve rapid blood pressure control to avoid end-organ damage. During the last decades, new antihypertensive medications have become available for management of hypertensive crisis. One of these agents is the calcium channel blocker nicardipine. Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients. Minimal data exist in the literature regarding the use of this medicine during pregnancy. The purpose of this article is to review the pharmacological properties of nicardipine, the available literature regarding its use during pregnancy, and potential interactions with other medicines used commonly in preeclampsia, as well as potential side effects directly affecting the peripartum period.
AB - Hypertensive disorders in pregnancy constitute one of the most frequent medical complications during gestation. Unfortunately, maternal and perinatal mortality remains significant worldwide in this population. Not infrequently, patients with severe preeclampsia will need parenteral agents to achieve rapid blood pressure control to avoid end-organ damage. During the last decades, new antihypertensive medications have become available for management of hypertensive crisis. One of these agents is the calcium channel blocker nicardipine. Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients. Minimal data exist in the literature regarding the use of this medicine during pregnancy. The purpose of this article is to review the pharmacological properties of nicardipine, the available literature regarding its use during pregnancy, and potential interactions with other medicines used commonly in preeclampsia, as well as potential side effects directly affecting the peripartum period.
KW - Hypertension
KW - Nicardipine
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=67749110408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67749110408&partnerID=8YFLogxK
U2 - 10.1055/s-0029-1214251
DO - 10.1055/s-0029-1214251
M3 - Article
C2 - 19396743
AN - SCOPUS:67749110408
VL - 26
SP - 495
EP - 499
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 7
ER -