Acute doxorubicin-induced cardiac arrhythmias during ether anesthesia

R. C. Aversano, P. J. Boor

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Acute intravenous administration of doxorubicin (30 and 50 mg/kg) elicited cardiac arrhythmias in the mouse, the severity and extent of which were dependent upon dose of doxorubicin and the anesthetic agent utilized. Fatal arrhythmias occurred in all mice given 50 mg/kg doxorubicin under ether anesthesia. Vasoactive amines may mediate the arrhythmogenicity of acute doxorubicin administration.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume41
Issue number2
StatePublished - 1983

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ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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