TY - JOUR
T1 - Acute effects of beer on endothelial function and hemodynamics
T2 - Asingle-blind, crossover study in healthy volunteers
AU - Karatzi, Kalliopi
AU - Rontoyanni, Victoria G.
AU - Protogerou, Athanase D.
AU - Georgoulia, Aggeliki
AU - Xenos, Konstantinos
AU - Chrysou, John
AU - Sfikakis, Petros P.
AU - Sidossis, Labros S.
N1 - Funding Information:
This work was supported in part by the Graduate Program, Department of Nutrition and Dietetics of Harokopio University , the Institute for Translational Sciences at the University of Texas Medical Branch (supported in part by a Clinical and Translational Science Award ( UL1TR000071 ) from the National Center for Advancing Translational Sciences ) and the Sealy Center on Aging, University of Texas Medical Branch at Galveston. We are indebted to the volunteers for their interest and participation in the study.
PY - 2013/9
Y1 - 2013/9
N2 - Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33%, 95% confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.
AB - Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33%, 95% confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.
KW - Alcohol
KW - Aortic pressure
KW - Arterial stiffness
KW - Beer
KW - Endothelial function
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U2 - 10.1016/j.nut.2013.02.016
DO - 10.1016/j.nut.2013.02.016
M3 - Article
C2 - 23810643
AN - SCOPUS:84881373576
SN - 0899-9007
VL - 29
SP - 1122
EP - 1126
JO - Nutrition
JF - Nutrition
IS - 9
ER -