Acute effects of beer on endothelial function and hemodynamics: Asingle-blind, crossover study in healthy volunteers

Kalliopi Karatzi, Victoria G. Rontoyanni, Athanase D. Protogerou, Aggeliki Georgoulia, Konstantinos Xenos, John Chrysou, Petros P. Sfikakis, Labros S. Sidossis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33%, 95% confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.

Original languageEnglish (US)
Pages (from-to)1122-1126
Number of pages5
JournalNutrition
Volume29
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Cross-Over Studies
Healthy Volunteers
Hemodynamics
Vascular Stiffness
Arterial Pressure
Arm
Alcohols
Antioxidants
Confidence Intervals
Single-Blind Method
Pulse Wave Analysis
Water
Polyphenols
Dilatation
Body Mass Index
Blood Pressure
Pressure
Equipment and Supplies

Keywords

  • Alcohol
  • Aortic pressure
  • Arterial stiffness
  • Beer
  • Endothelial function

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Karatzi, K., Rontoyanni, V. G., Protogerou, A. D., Georgoulia, A., Xenos, K., Chrysou, J., ... Sidossis, L. S. (2013). Acute effects of beer on endothelial function and hemodynamics: Asingle-blind, crossover study in healthy volunteers. Nutrition, 29(9), 1122-1126. https://doi.org/10.1016/j.nut.2013.02.016

Acute effects of beer on endothelial function and hemodynamics : Asingle-blind, crossover study in healthy volunteers. / Karatzi, Kalliopi; Rontoyanni, Victoria G.; Protogerou, Athanase D.; Georgoulia, Aggeliki; Xenos, Konstantinos; Chrysou, John; Sfikakis, Petros P.; Sidossis, Labros S.

In: Nutrition, Vol. 29, No. 9, 09.2013, p. 1122-1126.

Research output: Contribution to journalArticle

Karatzi, K, Rontoyanni, VG, Protogerou, AD, Georgoulia, A, Xenos, K, Chrysou, J, Sfikakis, PP & Sidossis, LS 2013, 'Acute effects of beer on endothelial function and hemodynamics: Asingle-blind, crossover study in healthy volunteers', Nutrition, vol. 29, no. 9, pp. 1122-1126. https://doi.org/10.1016/j.nut.2013.02.016
Karatzi K, Rontoyanni VG, Protogerou AD, Georgoulia A, Xenos K, Chrysou J et al. Acute effects of beer on endothelial function and hemodynamics: Asingle-blind, crossover study in healthy volunteers. Nutrition. 2013 Sep;29(9):1122-1126. https://doi.org/10.1016/j.nut.2013.02.016
Karatzi, Kalliopi ; Rontoyanni, Victoria G. ; Protogerou, Athanase D. ; Georgoulia, Aggeliki ; Xenos, Konstantinos ; Chrysou, John ; Sfikakis, Petros P. ; Sidossis, Labros S. / Acute effects of beer on endothelial function and hemodynamics : Asingle-blind, crossover study in healthy volunteers. In: Nutrition. 2013 ; Vol. 29, No. 9. pp. 1122-1126.
@article{eafd918b7acf4f318fa748f366f0e982,
title = "Acute effects of beer on endothelial function and hemodynamics: Asingle-blind, crossover study in healthy volunteers",
abstract = "Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33{\%}, 95{\%} confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1{\%}, dealcoholized beer: 2.8{\%}, vodka 8.5{\%}, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.",
keywords = "Alcohol, Aortic pressure, Arterial stiffness, Beer, Endothelial function",
author = "Kalliopi Karatzi and Rontoyanni, {Victoria G.} and Protogerou, {Athanase D.} and Aggeliki Georgoulia and Konstantinos Xenos and John Chrysou and Sfikakis, {Petros P.} and Sidossis, {Labros S.}",
year = "2013",
month = "9",
doi = "10.1016/j.nut.2013.02.016",
language = "English (US)",
volume = "29",
pages = "1122--1126",
journal = "Nutrition International",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Acute effects of beer on endothelial function and hemodynamics

T2 - Asingle-blind, crossover study in healthy volunteers

AU - Karatzi, Kalliopi

AU - Rontoyanni, Victoria G.

AU - Protogerou, Athanase D.

AU - Georgoulia, Aggeliki

AU - Xenos, Konstantinos

AU - Chrysou, John

AU - Sfikakis, Petros P.

AU - Sidossis, Labros S.

PY - 2013/9

Y1 - 2013/9

N2 - Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33%, 95% confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.

AB - Objective: Moderate consumption of beer is associated with lower cardiovascular (CV) risk. The goal of this study was to determine the effect of beer consumption on CV risk. To explore the underlying mechanisms, we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure. Methods: In a randomized, single-blind, crossover study, 17 healthy, non-smoking, men (ages 28.5± 5.2 y with body mass index 24.4 ± 2.5 kg/m2) consumed on three separate occasions, at least 1 wk apart: 1. 400 mL of beer and 400 mL water, 2. 800 mL of dealcoholized beer (same amount of polyphenols as in the 400 mL of beer), and 3. 67 mL of vodka and 733 mL water (same amount of alcohol as in the 400 mL of beer).Each time aortic stiffness (pulse wave velocity), pressure wave reflections (AΙx), aortic and brachial pressure (Sphygmocor device), and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 h postprandial. Results: Aortic stiffness was significantly and similarly reduced by all three interventions. However, endothelial function was significantly improved only after beer consumption (average 1.33%, 95% confidence interval [CI] 0.15-2.53). Although wave reflections were significantly reduced by all three interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared with dealcoholized beer (P= 0.018). Pulse pressure amplification (i.e., brachial/aortic) was increased by all three test drinks. Conclusions: Beer acutely improves parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and antioxidants and merits further investigation.

KW - Alcohol

KW - Aortic pressure

KW - Arterial stiffness

KW - Beer

KW - Endothelial function

UR - http://www.scopus.com/inward/record.url?scp=84881373576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881373576&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2013.02.016

DO - 10.1016/j.nut.2013.02.016

M3 - Article

C2 - 23810643

AN - SCOPUS:84881373576

VL - 29

SP - 1122

EP - 1126

JO - Nutrition International

JF - Nutrition International

SN - 0899-9007

IS - 9

ER -