Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance

Martin Westphal, Naoki Morita, Perenlei Enkhbaatar, Kazunori Murakami, Lillian Traber, Daniel Lee Traber

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The objective of this study was to determine the relationship between carboxyhemoglobin (COHb) formation, global oxygen transport, and cardiac performance in the acute phase of combined burn and smoke inhalation injury. Following a third degree burn of 20% of the total body surface area, adult sheep were subjected to cotton smoke (4×12 breaths) according to an established protocol. Compared with baseline (BL), the burn injury led to an immediate and sustained COHb-independent depression in myocardial contractility. Despite a progressive increase in COHb formation, up to a maximum of 78±3% (P<0.001 vs BL), smoke inhalation did not further impair these hemodynamic changes. This study demonstrated that in the early stage of combined burn and smoke inhalation injury, the depression in cardiac function is basically triggered by the burn injury, whereas COHb generation secondary to cotton smoke exposure primarily contributes to pulmonary shunting.

Original languageEnglish (US)
Pages (from-to)945-949
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume317
Issue number3
DOIs
StatePublished - May 7 2004

Fingerprint

Smoke Inhalation Injury
Carboxyhemoglobin
Oxygenation
Smoke
Tissue
Cotton
Body Surface Area
Wounds and Injuries
Inhalation
Hemodynamics
Sheep
Oxygen
Lung

Keywords

  • Bradykinin
  • Carboxyhemoglobin
  • Hemodynamics
  • Hypoxic pulmonary vasoconstriction
  • Lung
  • Oxygen delivery
  • Sheep
  • Thermal injury

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance. / Westphal, Martin; Morita, Naoki; Enkhbaatar, Perenlei; Murakami, Kazunori; Traber, Lillian; Traber, Daniel Lee.

In: Biochemical and Biophysical Research Communications, Vol. 317, No. 3, 07.05.2004, p. 945-949.

Research output: Contribution to journalArticle

Westphal, Martin ; Morita, Naoki ; Enkhbaatar, Perenlei ; Murakami, Kazunori ; Traber, Lillian ; Traber, Daniel Lee. / Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance. In: Biochemical and Biophysical Research Communications. 2004 ; Vol. 317, No. 3. pp. 945-949.
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