Acute effects of exercise and calorie restriction on triglyceride metabolism in women

Elena Bellou, Aikaterina Siopi, Maria Galani, Maria Maraki, Yiannis E. Tsekouras, Demosthenes B. Panagiotakos, Stavros A. Kavouras, Faidon Magkos, Labros S. Sidossis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE: The mechanisms by which exercise reduces fasting plasma triglyceride (TG) concentrations in women and the effect of negative energy balance independent of muscular contraction are not known.The aim of this study was to evaluate the effects of equivalent energy deficits induced by exercise or calorie restriction on basal VLDL-TG metabolism in women. METHODS: Eleven healthy women (age = 23.5 ± 2.7 yr, body mass index = 21.6 ± 1.4 kg·m; mean ± SD) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: (i) a single exercise bout (brisk walking at 60% of peak oxygen consumption for 123 ± 18 min, with a net energy expenditure of 2.06 ± 0.39 MJ, ∼500 kcal), (ii) dietary energy restriction of 2.10 ± 0.41 MJ, and (iii) a control day of isocaloric feeding and rest (zero energy balance). RESULTS: Fasting plasma VLDL-TG concentration was approximately 30% lower after the exercise trial compared with the control trial (P < 0.001), whereas no significant change was detected after the calorie restriction trial (P = 0.297 vs control). Relative to the control condition, exercise increased the plasma clearance rate of VLDL-TG by 22% (P = 0.001) and reduced hepatic VLDL-TG secretion rate by approximately 17% (P = 0.042), whereas hypocaloric diet had no effect on VLDL-TG kinetics (P > 0.2). CONCLUSION: (i) Exercise-induced hypotriglyceridemia in women manifests through a different mechanism (increased clearance and decreased secretion of VLDL-TG) than that previously described in men (increased clearance of VLDL-TG only), and (ii) exercise affects TG homeostasis by eliciting changes in VLDL-TG kinetics that cannot be reproduced by an equivalent diet-induced energy deficit, indicating that these changes are independent of the exercise-induced negative energy balance but instead are specific to muscular contraction.

Original languageEnglish (US)
Pages (from-to)455-461
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume45
Issue number3
DOIs
StatePublished - Mar 2013

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Triglycerides
Exercise
Muscle Contraction
Fasting
Oxygen Consumption
Energy Metabolism
Walking
very low density lipoprotein triglyceride
Body Mass Index
Homeostasis
Diet

Keywords

  • hypocaloric diet
  • hypotriglyceridemia
  • Physical activity
  • triglyceride

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Bellou, E., Siopi, A., Galani, M., Maraki, M., Tsekouras, Y. E., Panagiotakos, D. B., ... Sidossis, L. S. (2013). Acute effects of exercise and calorie restriction on triglyceride metabolism in women. Medicine and Science in Sports and Exercise, 45(3), 455-461. https://doi.org/10.1249/MSS.0b013e318278183e

Acute effects of exercise and calorie restriction on triglyceride metabolism in women. / Bellou, Elena; Siopi, Aikaterina; Galani, Maria; Maraki, Maria; Tsekouras, Yiannis E.; Panagiotakos, Demosthenes B.; Kavouras, Stavros A.; Magkos, Faidon; Sidossis, Labros S.

In: Medicine and Science in Sports and Exercise, Vol. 45, No. 3, 03.2013, p. 455-461.

Research output: Contribution to journalArticle

Bellou, E, Siopi, A, Galani, M, Maraki, M, Tsekouras, YE, Panagiotakos, DB, Kavouras, SA, Magkos, F & Sidossis, LS 2013, 'Acute effects of exercise and calorie restriction on triglyceride metabolism in women', Medicine and Science in Sports and Exercise, vol. 45, no. 3, pp. 455-461. https://doi.org/10.1249/MSS.0b013e318278183e
Bellou, Elena ; Siopi, Aikaterina ; Galani, Maria ; Maraki, Maria ; Tsekouras, Yiannis E. ; Panagiotakos, Demosthenes B. ; Kavouras, Stavros A. ; Magkos, Faidon ; Sidossis, Labros S. / Acute effects of exercise and calorie restriction on triglyceride metabolism in women. In: Medicine and Science in Sports and Exercise. 2013 ; Vol. 45, No. 3. pp. 455-461.
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