Acute otitis media and other complications of viral respiratory infection

Tasnee Chonmaitree, Rocio Trujillo, Kristofer Jennings, Pedro Alvarez-Fernandez, Janak Patel, Michael J. Loeffelholz, Johanna Nokso-Koivisto, Reuben Matalon, Richard Pyles, Aaron L. Miller, David P. McCormick

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Viral upper and lower respiratory tract infections (URI, LRI) are common in infants. We determined the prevalence of viral URI and its complications, including acute otitis media (AOM) and LRI, and assessed the effect of bacterial-viral interactions, and genetic and environmental risks on AOM development. METHODS: Healthy infants were enrolled from near birth and followed to the first episode of AOM up to 12 months of age. Nasopharyngeal specimens were collected at monthly intervals (months 1-6, 9) and during viral URI episodes for bacterial culture and viral polymerase chain reaction studies. Subjects were followed closely for AOM development. RESULTS: A total of 367 infants were followed for 286 child-years; 887 URI (305 infants) and 180 AOM episodes (143 infants) were documented. Prevalence of URI, LRI, and AOM in the first year was 3.2, 0.25, and 0.67 per child-year, respectively. Cumulative AOM incidence by ages 3, 6, and 12 months was 6%, 23%, and 46%. Infants with and without AOM had 4.7 and 2.3 URI episodes per child-year, respectively (P

Original languageEnglish (US)
JournalPediatrics
Volume137
Issue number4
DOIs
StatePublished - Apr 1 2016

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Otitis Media
Virus Diseases
Respiratory Tract Infections
Parturition
Polymerase Chain Reaction
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chonmaitree, T., Trujillo, R., Jennings, K., Alvarez-Fernandez, P., Patel, J., Loeffelholz, M. J., ... McCormick, D. P. (2016). Acute otitis media and other complications of viral respiratory infection. Pediatrics, 137(4). https://doi.org/10.1542/peds.2015-3555

Acute otitis media and other complications of viral respiratory infection. / Chonmaitree, Tasnee; Trujillo, Rocio; Jennings, Kristofer; Alvarez-Fernandez, Pedro; Patel, Janak; Loeffelholz, Michael J.; Nokso-Koivisto, Johanna; Matalon, Reuben; Pyles, Richard; Miller, Aaron L.; McCormick, David P.

In: Pediatrics, Vol. 137, No. 4, 01.04.2016.

Research output: Contribution to journalArticle

Chonmaitree, T, Trujillo, R, Jennings, K, Alvarez-Fernandez, P, Patel, J, Loeffelholz, MJ, Nokso-Koivisto, J, Matalon, R, Pyles, R, Miller, AL & McCormick, DP 2016, 'Acute otitis media and other complications of viral respiratory infection', Pediatrics, vol. 137, no. 4. https://doi.org/10.1542/peds.2015-3555
Chonmaitree T, Trujillo R, Jennings K, Alvarez-Fernandez P, Patel J, Loeffelholz MJ et al. Acute otitis media and other complications of viral respiratory infection. Pediatrics. 2016 Apr 1;137(4). https://doi.org/10.1542/peds.2015-3555
Chonmaitree, Tasnee ; Trujillo, Rocio ; Jennings, Kristofer ; Alvarez-Fernandez, Pedro ; Patel, Janak ; Loeffelholz, Michael J. ; Nokso-Koivisto, Johanna ; Matalon, Reuben ; Pyles, Richard ; Miller, Aaron L. ; McCormick, David P. / Acute otitis media and other complications of viral respiratory infection. In: Pediatrics. 2016 ; Vol. 137, No. 4.
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