Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone

We present two cases in which young, previously healthy adolescents developed acute pulmonary edema shortly after receiving small doses of naloxone for antagonism of residual narcotic drugs. These cases emphasize the need for cautious administration of naloxone and for careful observation of patients who receive naloxone to reverse narcotic effects, even if they have no history of hypertension or cardiovascular disease.