Acute renal dysfunction in severely burned adults

Minas T. Chrysopoiilo, Marc G. Jeschke, Peter Dzüewulski, Robert E. Barrow, David Herndon

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: Factors contributing to mortality in burned children with acute renal failure have been identified; however, they have not been identified in thermally injured adults. Methods: The records of 1,404 acutely burned adults admitted to the Blocker Burn Unit were reviewed. Seventy-six patients with acute renal dysfunction and burns covering more than 30% of their total body surface area with a full-thickness component greater than 10% total body surface area were identified. These patients were divided into those admitted from 1981 through 1989 (n = 35) and those admitted from 1990 to 1998 (n = 41). Results: No significant differences could be shown in the incidence of acute renal dysfunction (5.4 vs. 5.1%) or mortality (88 vs. 87%) for the two time periods, respectively. Sixty-seven percent of the survivors were younger than 40 years of age, compared with only 25% of nonsurvivors (p < 0.02); sepsis was identified in 44 and 96% of survivors and nonsurvivors, respectively (p < 0.001). Fluid resuscitation was delayed in survivors by 1.7 ± 1.0 hours compared with 4.4 ± 2.1 hours in nonsurvivors (p < 0.001). Conclusion: Early fluid resuscitation and the prevention of sepsis may reduce the incidence of acute renal dysfunction and mortality in burned adults.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume46
Issue number1
DOIs
StatePublished - Jan 1999

Fingerprint

Survivors
Body Surface Area
Kidney
Resuscitation
Mortality
Sepsis
Burn Units
Incidence
Burns
Acute Kidney Injury

Keywords

  • Burns
  • Fluid resuscitation
  • Renal dysfunction
  • Sepsis

ASJC Scopus subject areas

  • Surgery

Cite this

Chrysopoiilo, M. T., Jeschke, M. G., Dzüewulski, P., Barrow, R. E., & Herndon, D. (1999). Acute renal dysfunction in severely burned adults. Journal of Trauma - Injury, Infection and Critical Care, 46(1), 141-144. https://doi.org/10.1097/00005373-199901000-00024

Acute renal dysfunction in severely burned adults. / Chrysopoiilo, Minas T.; Jeschke, Marc G.; Dzüewulski, Peter; Barrow, Robert E.; Herndon, David.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 46, No. 1, 01.1999, p. 141-144.

Research output: Contribution to journalArticle

Chrysopoiilo, MT, Jeschke, MG, Dzüewulski, P, Barrow, RE & Herndon, D 1999, 'Acute renal dysfunction in severely burned adults', Journal of Trauma - Injury, Infection and Critical Care, vol. 46, no. 1, pp. 141-144. https://doi.org/10.1097/00005373-199901000-00024
Chrysopoiilo, Minas T. ; Jeschke, Marc G. ; Dzüewulski, Peter ; Barrow, Robert E. ; Herndon, David. / Acute renal dysfunction in severely burned adults. In: Journal of Trauma - Injury, Infection and Critical Care. 1999 ; Vol. 46, No. 1. pp. 141-144.
@article{982d8d02a7f941bfaec0bd9616c2c40e,
title = "Acute renal dysfunction in severely burned adults",
abstract = "Background: Factors contributing to mortality in burned children with acute renal failure have been identified; however, they have not been identified in thermally injured adults. Methods: The records of 1,404 acutely burned adults admitted to the Blocker Burn Unit were reviewed. Seventy-six patients with acute renal dysfunction and burns covering more than 30{\%} of their total body surface area with a full-thickness component greater than 10{\%} total body surface area were identified. These patients were divided into those admitted from 1981 through 1989 (n = 35) and those admitted from 1990 to 1998 (n = 41). Results: No significant differences could be shown in the incidence of acute renal dysfunction (5.4 vs. 5.1{\%}) or mortality (88 vs. 87{\%}) for the two time periods, respectively. Sixty-seven percent of the survivors were younger than 40 years of age, compared with only 25{\%} of nonsurvivors (p < 0.02); sepsis was identified in 44 and 96{\%} of survivors and nonsurvivors, respectively (p < 0.001). Fluid resuscitation was delayed in survivors by 1.7 ± 1.0 hours compared with 4.4 ± 2.1 hours in nonsurvivors (p < 0.001). Conclusion: Early fluid resuscitation and the prevention of sepsis may reduce the incidence of acute renal dysfunction and mortality in burned adults.",
keywords = "Burns, Fluid resuscitation, Renal dysfunction, Sepsis",
author = "Chrysopoiilo, {Minas T.} and Jeschke, {Marc G.} and Peter Dz{\"u}ewulski and Barrow, {Robert E.} and David Herndon",
year = "1999",
month = "1",
doi = "10.1097/00005373-199901000-00024",
language = "English (US)",
volume = "46",
pages = "141--144",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Acute renal dysfunction in severely burned adults

AU - Chrysopoiilo, Minas T.

AU - Jeschke, Marc G.

AU - Dzüewulski, Peter

AU - Barrow, Robert E.

AU - Herndon, David

PY - 1999/1

Y1 - 1999/1

N2 - Background: Factors contributing to mortality in burned children with acute renal failure have been identified; however, they have not been identified in thermally injured adults. Methods: The records of 1,404 acutely burned adults admitted to the Blocker Burn Unit were reviewed. Seventy-six patients with acute renal dysfunction and burns covering more than 30% of their total body surface area with a full-thickness component greater than 10% total body surface area were identified. These patients were divided into those admitted from 1981 through 1989 (n = 35) and those admitted from 1990 to 1998 (n = 41). Results: No significant differences could be shown in the incidence of acute renal dysfunction (5.4 vs. 5.1%) or mortality (88 vs. 87%) for the two time periods, respectively. Sixty-seven percent of the survivors were younger than 40 years of age, compared with only 25% of nonsurvivors (p < 0.02); sepsis was identified in 44 and 96% of survivors and nonsurvivors, respectively (p < 0.001). Fluid resuscitation was delayed in survivors by 1.7 ± 1.0 hours compared with 4.4 ± 2.1 hours in nonsurvivors (p < 0.001). Conclusion: Early fluid resuscitation and the prevention of sepsis may reduce the incidence of acute renal dysfunction and mortality in burned adults.

AB - Background: Factors contributing to mortality in burned children with acute renal failure have been identified; however, they have not been identified in thermally injured adults. Methods: The records of 1,404 acutely burned adults admitted to the Blocker Burn Unit were reviewed. Seventy-six patients with acute renal dysfunction and burns covering more than 30% of their total body surface area with a full-thickness component greater than 10% total body surface area were identified. These patients were divided into those admitted from 1981 through 1989 (n = 35) and those admitted from 1990 to 1998 (n = 41). Results: No significant differences could be shown in the incidence of acute renal dysfunction (5.4 vs. 5.1%) or mortality (88 vs. 87%) for the two time periods, respectively. Sixty-seven percent of the survivors were younger than 40 years of age, compared with only 25% of nonsurvivors (p < 0.02); sepsis was identified in 44 and 96% of survivors and nonsurvivors, respectively (p < 0.001). Fluid resuscitation was delayed in survivors by 1.7 ± 1.0 hours compared with 4.4 ± 2.1 hours in nonsurvivors (p < 0.001). Conclusion: Early fluid resuscitation and the prevention of sepsis may reduce the incidence of acute renal dysfunction and mortality in burned adults.

KW - Burns

KW - Fluid resuscitation

KW - Renal dysfunction

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=0032894997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032894997&partnerID=8YFLogxK

U2 - 10.1097/00005373-199901000-00024

DO - 10.1097/00005373-199901000-00024

M3 - Article

C2 - 9932697

AN - SCOPUS:0032894997

VL - 46

SP - 141

EP - 144

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 1

ER -