Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon

Lucy M. Ndip, Donald Bouyer, Amelia P A Travassos Da Rosa, V. P K Titanji, Robert B. Tesh, David Walker

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Although potential arthropod vectors are abundant in Cameroon, acute febrile illnesses are rarely evaluated for arboviral or rickettsial infections. Serum samples from 234 acutely febrile patients at clinics in Tiko and Buea, Cameroon, were examined for antibodies to Rickettsia africae and African alphaviruses and flaviviruses. These serum samples did not contain antibodies against typhoid, and blood malarial parasites were not detected. Serum samples of 32% contained immunoglobulin M antibodies reactive with R. africae by immunofluorescence assay and were reactive with outer membrane proteins A and B of R. africae by immunoblotting. These findings established a diagnosis of acute rickeftsiosis, most likely African tick-bite fever. Hemagglutination inhibition testing of the serum samples also detected antibodies to chikungunya virus (47%) and flaviviruses (47%). High prevalence of antibodies to arboviruses may represent a major, previously unrecognized public health problem in an area where endemic malaria and typhoid fever have been the principal diagnostic considerations.

Original languageEnglish (US)
Pages (from-to)432-437
Number of pages6
JournalEmerging Infectious Diseases
Volume10
Issue number3
StatePublished - Mar 2004

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Cameroon
Fever
Antibodies
Flavivirus
Typhoid Fever
Serum
Arthropod Vectors
Chikungunya virus
Tick Bites
Alphavirus
Arboviruses
Rickettsia
Hemagglutination
Immunoblotting
Malaria
Fluorescent Antibody Technique
Immunoglobulin M
Parasites
Public Health
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Ndip, L. M., Bouyer, D., Travassos Da Rosa, A. P. A., Titanji, V. P. K., Tesh, R. B., & Walker, D. (2004). Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon. Emerging Infectious Diseases, 10(3), 432-437.

Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon. / Ndip, Lucy M.; Bouyer, Donald; Travassos Da Rosa, Amelia P A; Titanji, V. P K; Tesh, Robert B.; Walker, David.

In: Emerging Infectious Diseases, Vol. 10, No. 3, 03.2004, p. 432-437.

Research output: Contribution to journalArticle

Ndip, LM, Bouyer, D, Travassos Da Rosa, APA, Titanji, VPK, Tesh, RB & Walker, D 2004, 'Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon', Emerging Infectious Diseases, vol. 10, no. 3, pp. 432-437.
Ndip LM, Bouyer D, Travassos Da Rosa APA, Titanji VPK, Tesh RB, Walker D. Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon. Emerging Infectious Diseases. 2004 Mar;10(3):432-437.
Ndip, Lucy M. ; Bouyer, Donald ; Travassos Da Rosa, Amelia P A ; Titanji, V. P K ; Tesh, Robert B. ; Walker, David. / Acute Spotted Fever Rickettsiosis among Febrile Patients, Cameroon. In: Emerging Infectious Diseases. 2004 ; Vol. 10, No. 3. pp. 432-437.
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