Acute tubular necrosis after renal allograft segmental infarction

The nephrotoxicity of necrotic material

Mohammad Reza Ardalan, Hamid Nasri, Kamyar Ghabili, Mohammadali Mohajel Shoja

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Renal allograft dysfunction can be caused by renal vessel thrombosis, acute tubular necrosis, hyper acute or acute rejection, nephrotoxicity induced by cyclosporine or tacrolimus, thrombotic microangiopathy, or urinary tract obstruction. Materials and Methods: We describe a renal transplant recipient in whom oliguria developed during the first week after transplant, although his early renal allograft function was good. Results: A Doppler ultrasonographic study revealed a lack of perfusion in the lower pole of the allograft. A perfusion defect was noted in the lower pole that was supplied by a polar artery, which had been damaged during engraftment. Light microscopy disclosed tubular cell necrosis without evidence of vascular or humoral rejection. Conclusions: We suggest that toxic molecules such as tumor necrosis factor-alpha released from a segmental infarcted area can induce tubular cell damage and necrosis leading to renal allograft dysfunction.

Original languageEnglish (US)
Pages (from-to)312-314
Number of pages3
JournalExperimental and Clinical Transplantation
Volume6
Issue number4
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Infarction
Allografts
Necrosis
Kidney
Perfusion
Thrombotic Microangiopathies
Oliguria
Poisons
Tacrolimus
Urinary Tract
Cyclosporine
Blood Vessels
Microscopy
Thrombosis
Arteries
Tumor Necrosis Factor-alpha
Transplants
Light

Keywords

  • Infarction
  • Kidney
  • Rejection
  • Transplant
  • Tubular necrosis

ASJC Scopus subject areas

  • Transplantation

Cite this

Acute tubular necrosis after renal allograft segmental infarction : The nephrotoxicity of necrotic material. / Ardalan, Mohammad Reza; Nasri, Hamid; Ghabili, Kamyar; Mohajel Shoja, Mohammadali.

In: Experimental and Clinical Transplantation, Vol. 6, No. 4, 01.12.2008, p. 312-314.

Research output: Contribution to journalArticle

Ardalan, Mohammad Reza ; Nasri, Hamid ; Ghabili, Kamyar ; Mohajel Shoja, Mohammadali. / Acute tubular necrosis after renal allograft segmental infarction : The nephrotoxicity of necrotic material. In: Experimental and Clinical Transplantation. 2008 ; Vol. 6, No. 4. pp. 312-314.
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