Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

Yuri P. Vedernikov, Ancizar Betancourt, Melissa J. Wentz, George Saade, Robert E. Garfield

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We tested the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V1A (VP) receptors, and that this depends on pregnancy. Study design: Concentration-contraction relationships (CCR) to OT and VP (10-12-10-6 mol/L) were obtained in different blood vessels. CCR were obtained in uterine arteries (UA) from nonpregnant, mid-pregnant, and late pregnant rats (n = 6-10 per group) in the absence and presence of selective antagonists (10-7 mol/L). Results: Sensitivity to OT, but not to VP, is attenuated in pregnant rat UA. Antagonists shifted CCR of OT and VP to the right, and, to a lesser extent, of the counterpart, in all UA. VP antagonist depresses oxytocin CCR much more than OT antagonist in pregnant rat UA. Conclusion: OT and VP contract UA via their own receptors, although partial cross-activation is evident. Adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.

Original languageEnglish (US)
Pages (from-to)252-260
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume194
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Uterine Artery
Oxytocin
Smooth Muscle
Pregnancy
Vasopressins
Contracts
Blood Vessels
Oxytocin Receptors
Vasopressin Receptors

Keywords

  • Oxytocin
  • Receptors
  • Uterine artery
  • Vascular adaptation to pregnancy
  • Vasopressin

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin. / Vedernikov, Yuri P.; Betancourt, Ancizar; Wentz, Melissa J.; Saade, George; Garfield, Robert E.

In: American Journal of Obstetrics and Gynecology, Vol. 194, No. 1, 01.2006, p. 252-260.

Research output: Contribution to journalArticle

Vedernikov, Yuri P. ; Betancourt, Ancizar ; Wentz, Melissa J. ; Saade, George ; Garfield, Robert E. / Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 194, No. 1. pp. 252-260.
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