Adeno-associated virus serotype 9-expressed zmapp in mice confers protection against systemic and airway-acquired ebola virus infection

Maria P. Limberis; Anna Tretiakova; Kalyani Nambiar; Gary Wong; Trina Racine; Marco Crosariol; Qiu Xiangguo; Gary Kobinger; James M. Wilson

doi:10.1093/infdis/jiw460

Adeno-associated virus serotype 9-expressed zmapp in mice confers protection against systemic and airway-acquired ebola virus infection

Maria P. Limberis, Anna Tretiakova, Kalyani Nambiar, Gary Wong, Trina Racine, Marco Crosariol, Qiu Xiangguo, Gary Kobinger, James M. Wilson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.

Original language	English (US)
Pages (from-to)	1975-1979
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	214
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiw460
State	Published - Dec 1 2016
Externally published	Yes

Keywords

Airway
Animals
Infectious disease
Prophylaxis
Protection
Vaccine
Vector
Virus

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiw460

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title = "Adeno-associated virus serotype 9-expressed zmapp in mice confers protection against systemic and airway-acquired ebola virus infection",

abstract = "Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.",

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AU - Limberis, Maria P.

AU - Tretiakova, Anna

AU - Nambiar, Kalyani

AU - Wong, Gary

AU - Racine, Trina

AU - Crosariol, Marco

AU - Xiangguo, Qiu

AU - Kobinger, Gary

AU - Wilson, James M.

N1 - Publisher Copyright: © The Author 2016.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.

AB - Adeno-associated viral vectors can be used as a platform for delivering biological countermeasures against pandemic and biological threats. We show that vector delivery of two antibody components of the ZMapp product is effective in mice against systemic and airway challenge with a mouse-adapted strain of Ebola virus. This platform provides a generic manufacturing solution and overcomes some of the delivery challenges associated with repeated administration of the protective protein.

KW - Airway

KW - Animals

KW - Infectious disease

KW - Prophylaxis

KW - Protection

KW - Vaccine

KW - Vector

KW - Virus

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SN - 0022-1899

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Adeno-associated virus serotype 9-expressed zmapp in mice confers protection against systemic and airway-acquired ebola virus infection

Abstract

Keywords

ASJC Scopus subject areas

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