Adenosine analog NITD008 is a potent inhibitor of zika virus

Yong Qiang Deng, Na Na Zhang, Chun Feng Li, Min Tian, Jia Nan Hao, Xuping Xie, Pei-Yong Shi, Cheng Feng Qin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.

Original languageEnglish (US)
Article numberofw175
JournalOpen Forum Infectious Diseases
Volume3
Issue number4
DOIs
StatePublished - 2016

Fingerprint

Adenosine
Antiviral Agents
Viremia
Drug Discovery
Disease Outbreaks
Zika Virus
NITD008
Emergencies
Mortality

Keywords

  • Adenosine analog
  • Antiviral
  • Mouse model
  • Zika virus

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X., ... Qin, C. F. (2016). Adenosine analog NITD008 is a potent inhibitor of zika virus. Open Forum Infectious Diseases, 3(4), [ofw175]. https://doi.org/10.1093/ofid/ofw175

Adenosine analog NITD008 is a potent inhibitor of zika virus. / Deng, Yong Qiang; Zhang, Na Na; Li, Chun Feng; Tian, Min; Hao, Jia Nan; Xie, Xuping; Shi, Pei-Yong; Qin, Cheng Feng.

In: Open Forum Infectious Diseases, Vol. 3, No. 4, ofw175, 2016.

Research output: Contribution to journalArticle

Deng, YQ, Zhang, NN, Li, CF, Tian, M, Hao, JN, Xie, X, Shi, P-Y & Qin, CF 2016, 'Adenosine analog NITD008 is a potent inhibitor of zika virus', Open Forum Infectious Diseases, vol. 3, no. 4, ofw175. https://doi.org/10.1093/ofid/ofw175
Deng, Yong Qiang ; Zhang, Na Na ; Li, Chun Feng ; Tian, Min ; Hao, Jia Nan ; Xie, Xuping ; Shi, Pei-Yong ; Qin, Cheng Feng. / Adenosine analog NITD008 is a potent inhibitor of zika virus. In: Open Forum Infectious Diseases. 2016 ; Vol. 3, No. 4.
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