Adenosine analog NITD008 is a potent inhibitor of zika virus

Yong Qiang Deng; Na Na Zhang; Chun Feng Li; Min Tian; Jia Nan Hao; Xu Ping Xie; Pei Yong Shi; Cheng Feng Qin

doi:10.1093/ofid/ofw175

Adenosine analog NITD008 is a potent inhibitor of zika virus

Yong Qiang Deng, Na Na Zhang, Chun Feng Li, Min Tian, Jia Nan Hao, Xu Ping Xie, Pei Yong Shi, Cheng Feng Qin

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article

77 Scopus citations

Abstract

The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	3
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofw175
State	Published - 2016

Keywords

Adenosine analog
Antiviral
Mouse model
Zika virus

ASJC Scopus subject areas

Oncology
Clinical Neurology

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10.1093/ofid/ofw175

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abstract = "The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.",

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AU - Deng, Yong Qiang

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AU - Li, Chun Feng

AU - Tian, Min

AU - Hao, Jia Nan

AU - Xie, Xu Ping

AU - Shi, Pei Yong

AU - Qin, Cheng Feng

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AB - The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.

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