Abstract
The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
| Original language | English (US) |
|---|---|
| Article number | ofw175 |
| Journal | Open Forum Infectious Diseases |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2016 |
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Keywords
- Adenosine analog
- Antiviral
- Mouse model
- Zika virus
ASJC Scopus subject areas
- Oncology
- Clinical Neurology
Cite this
Adenosine analog NITD008 is a potent inhibitor of zika virus. / Deng, Yong Qiang; Zhang, Na Na; Li, Chun Feng; Tian, Min; Hao, Jia Nan; Xie, Xuping; Shi, Pei-Yong; Qin, Cheng Feng.
In: Open Forum Infectious Diseases, Vol. 3, No. 4, ofw175, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenosine analog NITD008 is a potent inhibitor of zika virus
AU - Deng, Yong Qiang
AU - Zhang, Na Na
AU - Li, Chun Feng
AU - Tian, Min
AU - Hao, Jia Nan
AU - Xie, Xuping
AU - Shi, Pei-Yong
AU - Qin, Cheng Feng
PY - 2016
Y1 - 2016
N2 - The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
AB - The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.
KW - Adenosine analog
KW - Antiviral
KW - Mouse model
KW - Zika virus
UR - http://www.scopus.com/inward/record.url?scp=84996504031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84996504031&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofw175
DO - 10.1093/ofid/ofw175
M3 - Article
AN - SCOPUS:84996504031
VL - 3
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 4
M1 - ofw175
ER -