@article{1a23cc0fd8eb45f78a653f2bde9b9080,
title = "Adenosine analog NITD008 is a potent inhibitor of zika virus",
abstract = "The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery.",
keywords = "Adenosine analog, Antiviral, Mouse model, Zika virus",
author = "Deng, {Yong Qiang} and Zhang, {Na Na} and Li, {Chun Feng} and Min Tian and Hao, {Jia Nan} and Xie, {Xu Ping} and Shi, {Pei Yong} and Qin, {Cheng Feng}",
note = "Funding Information: This work was supported by the State Key Laboratory of Pathogen and Biosecurity (SKLPBS1601), the Guangzhou Science and Technology Program for Public Wellbeing (2014Y2-00185, No. 2014Y2-00550), and the National Natural Science Foundation (NSFC) of China (No. 31470265). C.-F. Q. was supported by the Excellent Young Scientist Program from the NSFC of China (No. 81522025) and the Newton Advanced Fellowship from the Academy of Medical Sciences, UK and the NSFC of China (No. 81661130162). PYS's group is supported by NIH grant (AI087856). Publisher Copyright: {\textcopyright} The Author 2016.",
year = "2016",
month = oct,
day = "1",
doi = "10.1093/ofid/ofw175",
language = "English (US)",
volume = "3",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "4",
}