Adenosine receptors

Therapeutic aspects for inflammatory and immune diseases

György Haskó, Bruce N. Cronstein, Csaba Szabo

Research output: Book/ReportBook

2 Citations (Scopus)

Abstract

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature. Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.

Original languageEnglish (US)
PublisherCRC Press
Number of pages363
ISBN (Electronic)9781420005776
ISBN (Print)0849339995, 9780849339998
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Purinergic P1 Receptors
Immune System Diseases
Adenosine
Research Personnel
Therapeutics
Aptitude
Central Nervous System Diseases
Reperfusion Injury
Mood Disorders
Wound Healing
Autoimmune Diseases
Reperfusion
Cell Biology
Molecular Biology
Immune System
Heart Diseases
Epilepsy
Neoplasms
Atherosclerosis
Ischemia

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)

Cite this

Adenosine receptors : Therapeutic aspects for inflammatory and immune diseases. / Haskó, György; Cronstein, Bruce N.; Szabo, Csaba.

CRC Press, 2006. 363 p.

Research output: Book/ReportBook

Haskó, György ; Cronstein, Bruce N. ; Szabo, Csaba. / Adenosine receptors : Therapeutic aspects for inflammatory and immune diseases. CRC Press, 2006. 363 p.
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