Adenovirus-based genetic vaccines for biodefense

Julie L. Boyer, Gary Kobinger, James M. Wilson, Ronald G. Crystal

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

The robust host responses elicited against transgenes encoded by E1 -E3- adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

Original languageEnglish (US)
Pages (from-to)157-168
Number of pages12
JournalHuman Gene Therapy
Volume16
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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