Adipokines and lipoproteins: Modulation by antihyperglycemic and hypolipidemic agents

Ali A. Rizvi, Dragana Nikolic, Hanaa S. Sallam, Giuseppe Montalto, Manfredi Rizzo, Nicola Abate

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Adipose tissue is an endocrine organ that secretes a number of hormones and metabolically active substances that impact energy metabolism and insulin sensitivity. These inflammatory markers are collectively referred to as adipocytokines, or adipokines. Adipose tissue's functional capacity and metabolic activity vary among individuals, thus partly explaining the incomplete overlap between obesity and the metabolic syndrome. The functional failure of adipose tissues results in changed energy delivery and impaired glucose consumption, triggering self-regulatory mechanisms to maintain homeostasis. Antihyperglycemic, hypolipidemic, antiobesity, and angiotensin II receptor blocker drugs influence adipokine levels in different ways. However, clinical data are still scarce and the clinical relevance of these effects needs to be fully determined.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalMetabolic Syndrome and Related Disorders
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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