Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults

Mark D. Peterson, Soham Al Snih al snih, Jonathan Stoddard, James McClain, I. Min Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVES: The purpose of this study is to compare the extent to which different combinations of objectively measured sedentary behavior (SB) and physical activity contribute to cardiometabolic health. DESIGN AND METHODS: A population representative sample of 5268 individuals, ages 20-85 yr, was included from the combined 2003-2006 National Health and Nutrition Examination Survey datasets. Activity categories were created on the combined basis of objectively measured SB and moderate-to-vigorous physical activity (MVPA) tertiles. Cardiometabolic abnormalities included elevated blood pressure, levels of triglycerides, fasting plasma glucose, C-reactive protein, homeostasis model assessment of insulin resistance value, and low HDL cholesterol level. Body mass index and dual-energy x-ray absorptiometry-derived percent body fat and android adiposity were also compared across groups. Predictors for a metabolically abnormal phenotype (=3 cardiometabolic abnormalities or insulin resistance) were determined. RESULTS: Adults with the least SB and greatest MVPA exhibited the healthiest cardiometabolic profiles, whereas adults with the greatest SB and lowest MVPA were older and had elevated risk. Time spent in SB was not a predictor of the metabolically abnormal phenotype when MVPA was accounted for. Adults with the highest MVPA across SB tertiles did not differ markedly in prevalence of obesity, adiposity, and/or serum cardiometabolic risk factors; however, less MVPA was associated with substantial elevations of obesity and cardiometabolic risk. Android adiposity (per kilogram) was independently associated with the metabolically abnormal phenotype in both men (odds ratio, 2.36 (95% CI, 1.76-3.17), P < 0.001) and women (odds ratio, 2.00 (95% CI, 1.63-2.45), P < 0.001). Among women, greater SB and less lifestyle moderate activity and MVPA were each independently associated with the metabolically abnormal phenotype, whereas only less MVPA was associated with it in men. CONCLUSIONS: MVPA is a strong predictor of cardiometabolic health among adults, independent of time spent in SB.

Original languageEnglish (US)
Pages (from-to)1133-1139
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume46
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Adiposity
Exercise
Phenotype
Insulin Resistance
Obesity
Odds Ratio
Nutrition Surveys
Health
C-Reactive Protein
HDL Cholesterol
Adipose Tissue
Life Style
Fasting
Triglycerides
Body Mass Index
Homeostasis
X-Rays
Blood Pressure
Glucose

Keywords

  • ACCELEROMETRY
  • ADIPOSITY
  • EXERCISE
  • INSULIN RESISTANCE
  • SITTING TIME

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)

Cite this

Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults. / Peterson, Mark D.; Al Snih al snih, Soham; Stoddard, Jonathan; McClain, James; Lee, I. Min.

In: Medicine and Science in Sports and Exercise, Vol. 46, No. 6, 2014, p. 1133-1139.

Research output: Contribution to journalArticle

Peterson, Mark D. ; Al Snih al snih, Soham ; Stoddard, Jonathan ; McClain, James ; Lee, I. Min. / Adiposity and insufficient MVPA predict cardiometabolic abnormalities in adults. In: Medicine and Science in Sports and Exercise. 2014 ; Vol. 46, No. 6. pp. 1133-1139.
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AU - Al Snih al snih, Soham

AU - Stoddard, Jonathan

AU - McClain, James

AU - Lee, I. Min

PY - 2014

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N2 - OBJECTIVES: The purpose of this study is to compare the extent to which different combinations of objectively measured sedentary behavior (SB) and physical activity contribute to cardiometabolic health. DESIGN AND METHODS: A population representative sample of 5268 individuals, ages 20-85 yr, was included from the combined 2003-2006 National Health and Nutrition Examination Survey datasets. Activity categories were created on the combined basis of objectively measured SB and moderate-to-vigorous physical activity (MVPA) tertiles. Cardiometabolic abnormalities included elevated blood pressure, levels of triglycerides, fasting plasma glucose, C-reactive protein, homeostasis model assessment of insulin resistance value, and low HDL cholesterol level. Body mass index and dual-energy x-ray absorptiometry-derived percent body fat and android adiposity were also compared across groups. Predictors for a metabolically abnormal phenotype (=3 cardiometabolic abnormalities or insulin resistance) were determined. RESULTS: Adults with the least SB and greatest MVPA exhibited the healthiest cardiometabolic profiles, whereas adults with the greatest SB and lowest MVPA were older and had elevated risk. Time spent in SB was not a predictor of the metabolically abnormal phenotype when MVPA was accounted for. Adults with the highest MVPA across SB tertiles did not differ markedly in prevalence of obesity, adiposity, and/or serum cardiometabolic risk factors; however, less MVPA was associated with substantial elevations of obesity and cardiometabolic risk. Android adiposity (per kilogram) was independently associated with the metabolically abnormal phenotype in both men (odds ratio, 2.36 (95% CI, 1.76-3.17), P < 0.001) and women (odds ratio, 2.00 (95% CI, 1.63-2.45), P < 0.001). Among women, greater SB and less lifestyle moderate activity and MVPA were each independently associated with the metabolically abnormal phenotype, whereas only less MVPA was associated with it in men. CONCLUSIONS: MVPA is a strong predictor of cardiometabolic health among adults, independent of time spent in SB.

AB - OBJECTIVES: The purpose of this study is to compare the extent to which different combinations of objectively measured sedentary behavior (SB) and physical activity contribute to cardiometabolic health. DESIGN AND METHODS: A population representative sample of 5268 individuals, ages 20-85 yr, was included from the combined 2003-2006 National Health and Nutrition Examination Survey datasets. Activity categories were created on the combined basis of objectively measured SB and moderate-to-vigorous physical activity (MVPA) tertiles. Cardiometabolic abnormalities included elevated blood pressure, levels of triglycerides, fasting plasma glucose, C-reactive protein, homeostasis model assessment of insulin resistance value, and low HDL cholesterol level. Body mass index and dual-energy x-ray absorptiometry-derived percent body fat and android adiposity were also compared across groups. Predictors for a metabolically abnormal phenotype (=3 cardiometabolic abnormalities or insulin resistance) were determined. RESULTS: Adults with the least SB and greatest MVPA exhibited the healthiest cardiometabolic profiles, whereas adults with the greatest SB and lowest MVPA were older and had elevated risk. Time spent in SB was not a predictor of the metabolically abnormal phenotype when MVPA was accounted for. Adults with the highest MVPA across SB tertiles did not differ markedly in prevalence of obesity, adiposity, and/or serum cardiometabolic risk factors; however, less MVPA was associated with substantial elevations of obesity and cardiometabolic risk. Android adiposity (per kilogram) was independently associated with the metabolically abnormal phenotype in both men (odds ratio, 2.36 (95% CI, 1.76-3.17), P < 0.001) and women (odds ratio, 2.00 (95% CI, 1.63-2.45), P < 0.001). Among women, greater SB and less lifestyle moderate activity and MVPA were each independently associated with the metabolically abnormal phenotype, whereas only less MVPA was associated with it in men. CONCLUSIONS: MVPA is a strong predictor of cardiometabolic health among adults, independent of time spent in SB.

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KW - INSULIN RESISTANCE

KW - SITTING TIME

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