Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients

Srinivasa Reddy Bonam, Srini V. Kaveri, Anavaj Sakuntabhai, Laurent Gilardin, Jagadeesh Bayry

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000 fatal cases as of May 8, 2020. Currently, there are no specific COVID-19 therapies. Most patients depend on mechanical ventilation. Current COVID-19 data clearly highlight that cytokine storm and activated immune cell migration to the lungs characterize the early immune response to COVID-19 that causes severe lung damage and development of acute respiratory distress syndrome. In view of uncertainty associated with immunosuppressive treatments, such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. Such immunotherapies based on inflammatory cytokine neutralization, immunomodulation, and passive viral neutralization not only reduce inflammation, inflammation-associated lung damage, or viral load but could also prevent intensive care unit hospitalization and dependency on mechanical ventilation, both of which are limited resources.

Original languageEnglish (US)
Article number100016
JournalCell Reports Medicine
Volume1
Issue number2
DOIs
StatePublished - May 19 2020
Externally publishedYes

Keywords

  • COVID-19
  • IVIG
  • SARS-CoV-2
  • convalescent plasma
  • cytokine storm syndrome
  • cytokines
  • hyperimmune globulin
  • immunotherapy
  • inflammation
  • monoclonal antibody
  • passive immunotherapy

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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