Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma

Jamie S K Takayesu; Upendra Parvathaneni; George E Laramore; Neil Panjwani; Jennifer Sillings; Neal D Futran; Ian M Humphreys; Aria Jafari; Waleed M Abuzeid; Brittany Barber; Emily Marchiano; Sylvia M Lee; John A Thompson; Evan Hall; Shailender Bhatia; Cristina P Rodriguez; Jay J Liao

doi:10.1002/cnr2.70111

Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma

Jamie S K Takayesu, Upendra Parvathaneni, George E Laramore, Neil Panjwani, Jennifer Sillings, Neal D Futran, Ian M Humphreys, Aria Jafari, Waleed M Abuzeid, Brittany Barber, Emily Marchiano, Sylvia M Lee, John A Thompson, Evan Hall, Shailender Bhatia, Cristina P Rodriguez, Jay J Liao

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.

AIMS: We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan-Meier estimates were used for survival analyses.

METHODS AND RESULTS: Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow-up was 15 months (range: 3-68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan-Meier 1-year results were as follows: local control 88%, distant metastasis-free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.

CONCLUSION: Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi-institutional work is needed to study this rare malignancy.

Original language	English (US)
Pages (from-to)	e70111
Journal	Cancer Reports
Volume	8
Issue number	2
DOIs	https://doi.org/10.1002/cnr2.70111
State	Published - Feb 2025

Keywords

Humans
Melanoma/radiotherapy
Proton Therapy/methods
Male
Female
Retrospective Studies
Aged
Radiotherapy, Adjuvant/methods
Middle Aged
Paranasal Sinus Neoplasms/radiotherapy
Nasal Mucosa/radiation effects
Aged, 80 and over
Adult
Follow-Up Studies

Access to Document

10.1002/cnr2.70111

Cite this

Takayesu, J. S. K., Parvathaneni, U., Laramore, G. E., Panjwani, N., Sillings, J., Futran, N. D., Humphreys, I. M., Jafari, A., Abuzeid, W. M., Barber, B., Marchiano, E., Lee, S. M., Thompson, J. A., Hall, E., Bhatia, S., Rodriguez, C. P., & Liao, J. J. (2025). Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma. Cancer Reports, 8(2), e70111. https://doi.org/10.1002/cnr2.70111

Takayesu, JSK, Parvathaneni, U, Laramore, GE, Panjwani, N, Sillings, J, Futran, ND, Humphreys, IM, Jafari, A, Abuzeid, WM, Barber, B, Marchiano, E, Lee, SM, Thompson, JA, Hall, E, Bhatia, S, Rodriguez, CP & Liao, JJ 2025, 'Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma', Cancer Reports, vol. 8, no. 2, pp. e70111. https://doi.org/10.1002/cnr2.70111

@article{824a3aec88e84a49b6d7cf97ed3e7497,

title = "Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma",

abstract = "BACKGROUND: Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.AIMS: We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan-Meier estimates were used for survival analyses.METHODS AND RESULTS: Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow-up was 15 months (range: 3-68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan-Meier 1-year results were as follows: local control 88%, distant metastasis-free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.CONCLUSION: Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi-institutional work is needed to study this rare malignancy.",

keywords = "Humans, Melanoma/radiotherapy, Proton Therapy/methods, Male, Female, Retrospective Studies, Aged, Radiotherapy, Adjuvant/methods, Middle Aged, Paranasal Sinus Neoplasms/radiotherapy, Nasal Mucosa/radiation effects, Aged, 80 and over, Adult, Follow-Up Studies",

author = "Takayesu, {Jamie S K} and Upendra Parvathaneni and Laramore, {George E} and Neil Panjwani and Jennifer Sillings and Futran, {Neal D} and Humphreys, {Ian M} and Aria Jafari and Abuzeid, {Waleed M} and Brittany Barber and Emily Marchiano and Lee, {Sylvia M} and Thompson, {John A} and Evan Hall and Shailender Bhatia and Rodriguez, {Cristina P} and Liao, {Jay J}",

note = "{\textcopyright} 2025 The Author(s). Cancer Reports published by Wiley Periodicals LLC.",

year = "2025",

month = feb,

doi = "10.1002/cnr2.70111",

language = "English (US)",

volume = "8",

pages = "e70111",

journal = "Cancer Reports",

issn = "2573-8348",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma

AU - Takayesu, Jamie S K

AU - Parvathaneni, Upendra

AU - Laramore, George E

AU - Panjwani, Neil

AU - Sillings, Jennifer

AU - Futran, Neal D

AU - Humphreys, Ian M

AU - Jafari, Aria

AU - Abuzeid, Waleed M

AU - Barber, Brittany

AU - Marchiano, Emily

AU - Lee, Sylvia M

AU - Thompson, John A

AU - Hall, Evan

AU - Bhatia, Shailender

AU - Rodriguez, Cristina P

AU - Liao, Jay J

PY - 2025/2

Y1 - 2025/2

N2 - BACKGROUND: Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.AIMS: We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan-Meier estimates were used for survival analyses.METHODS AND RESULTS: Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow-up was 15 months (range: 3-68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan-Meier 1-year results were as follows: local control 88%, distant metastasis-free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.CONCLUSION: Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi-institutional work is needed to study this rare malignancy.

AB - BACKGROUND: Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.AIMS: We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan-Meier estimates were used for survival analyses.METHODS AND RESULTS: Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow-up was 15 months (range: 3-68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan-Meier 1-year results were as follows: local control 88%, distant metastasis-free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.CONCLUSION: Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi-institutional work is needed to study this rare malignancy.

KW - Humans

KW - Melanoma/radiotherapy

KW - Proton Therapy/methods

KW - Male

KW - Female

KW - Retrospective Studies

KW - Aged

KW - Radiotherapy, Adjuvant/methods

KW - Middle Aged

KW - Paranasal Sinus Neoplasms/radiotherapy

KW - Nasal Mucosa/radiation effects

KW - Aged, 80 and over

KW - Adult

KW - Follow-Up Studies

U2 - 10.1002/cnr2.70111

DO - 10.1002/cnr2.70111

M3 - Article

C2 - 39907094

SN - 2573-8348

VL - 8

SP - e70111

JO - Cancer Reports

JF - Cancer Reports

IS - 2

ER -

Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma

Abstract

Keywords

Access to Document

Fingerprint

Cite this