Adjuvants: Making Vaccines Immunogenic

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The utilization of recombinant proteins in vaccines is advantageous from a safety perspective, but these proteins often are very poor at inducing an immune response. In this circumstance, the vaccine antigen can be delivered with substances known as adjuvants to increase the magnitude or duration of the immune response. This chapter examines the characteristics of a good adjuvant, the different types of adjuvants currently licensed or under development in the United States and European Union, and what is known about their mechanism of action. Future trends in adjuvant-driven development of specific types of immune responses and development of novel adjuvants for antigen delivery to specific tissues are also discussed.

Original languageEnglish (US)
Title of host publicationVaccinology: An Essential Guide
PublisherWiley Blackwell
Pages93-108
Number of pages16
ISBN (Electronic)9781118638033
ISBN (Print)9780470656167
DOIs
StatePublished - Dec 9 2014

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Keywords

  • Adjuvants
  • Alum
  • Antigens
  • Emulsion
  • Human vaccines
  • Pathogen recognition receptors
  • Pathogen-associated molecular patterns
  • Reactogenicity
  • Veterinary vaccines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Milligan, G. (2014). Adjuvants: Making Vaccines Immunogenic. In Vaccinology: An Essential Guide (pp. 93-108). Wiley Blackwell. https://doi.org/10.1002/9781118638033.ch6