Administration of Nonsteroidal Anti-inflammatory Agents in Patients With Rheumatoid Arthritis: Effects on Indexes of Cellular Immune Status and Serum Rheumatoid Factor Levels

James S. Goodwin, Jan L. Ceuppens, Martin A. Rodriguez

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We have previously reported that nonsteroidal anti-inflammatory agents (NSAIAs) stimulate cellular immune responses and inhibit production of IgM rheumatoid factor in cultures of lymphocytes from patients with rheumatoid arthritis. We had 20 patients with rheumatoid arthritis stop taking NSAIAs for two weeks and then take piroxicam, a new NSAIA, for an additional ten weeks to assess the in vivo effects of NSAIAs on cellular immunity and rheumatoid factor levels. In each case, serum rheumatoid factor levels rose and phytohemagglutinin response fell when placebo was substituted for NSAIAs. Piroxicam administration was associated with a fall in rheumatoid factor levels to approximately 62% of the baseline level and with an increase in phytohemagglutinin response. The action of NSAIAs in rheumatoid arthritis may be mediated to a degree by partial correction of the disordered immunoregulation in this disease.

Original languageEnglish (US)
Pages (from-to)2485-2488
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume250
Issue number18
DOIs
StatePublished - Nov 11 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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