TY - JOUR
T1 - Adrenal gland volume assessed by magnetic resonance imaging in women with polycystic ovary syndrome
AU - Unlu, E.
AU - Unlu, B. S.
AU - Yildiz, Y.
AU - Beker-Acay, M.
AU - Kacar, E.
AU - Turamanlar, O.
AU - Tulmac, O. B.
AU - Seven, A.
AU - Ozuguz, U.
N1 - Publisher Copyright:
© 2015 Éditions françaises de radiologie
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose To determine adrenal gland volume (AGV) in women with polycystic ovary syndrome (PCOS) by comparison with healthy control subjects and to investigate the relationship between AGV and hormonal status. Patients and methods AGV was measured on transverse sections of T1-weighted MRI imaging data in 27 PCOS patients and 40 age-matched control subjects for this prospectively designed study. A comparative analysis of AGV in PCOS and controls was performed and possible correlations between AGV and hormonal parameters were evaluated. Results PCOS patients had significantly larger AGV compared to controls ((11.7 ± 4.4 cm3, 7.2 ± 1.9 cm3, respectively, P < 0.001). A significant positive correlation was found between total AGV and dehydroepiandrosterone sulfate, 17-OH progesterone, and total and free testosterone levels in the PCOS group (r = +0.51, +0.48, +0.43, +0.62, respectively; P values < 0.05). In addition, AGV was significantly negatively correlated with LH and LH/FSH ratio in the PCOS group (r = −0.55, P = 0.02; r = −0.51, P = 0.01, respectively). Conclusions PCOS patients have significantly increased AGV as well as a positive correlation of AGV and androgens. We conclude that the assessment of AGV with MRI shows a significant correlation with the androgenic activity of the gland, and that hypertrophy of the adrenal gland may be involved in the pathogenesis of PCOS.
AB - Purpose To determine adrenal gland volume (AGV) in women with polycystic ovary syndrome (PCOS) by comparison with healthy control subjects and to investigate the relationship between AGV and hormonal status. Patients and methods AGV was measured on transverse sections of T1-weighted MRI imaging data in 27 PCOS patients and 40 age-matched control subjects for this prospectively designed study. A comparative analysis of AGV in PCOS and controls was performed and possible correlations between AGV and hormonal parameters were evaluated. Results PCOS patients had significantly larger AGV compared to controls ((11.7 ± 4.4 cm3, 7.2 ± 1.9 cm3, respectively, P < 0.001). A significant positive correlation was found between total AGV and dehydroepiandrosterone sulfate, 17-OH progesterone, and total and free testosterone levels in the PCOS group (r = +0.51, +0.48, +0.43, +0.62, respectively; P values < 0.05). In addition, AGV was significantly negatively correlated with LH and LH/FSH ratio in the PCOS group (r = −0.55, P = 0.02; r = −0.51, P = 0.01, respectively). Conclusions PCOS patients have significantly increased AGV as well as a positive correlation of AGV and androgens. We conclude that the assessment of AGV with MRI shows a significant correlation with the androgenic activity of the gland, and that hypertrophy of the adrenal gland may be involved in the pathogenesis of PCOS.
KW - Adrenal gland volume
KW - Magnetic resonance imaging
KW - Polycystic ovary syndrome
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U2 - 10.1016/j.diii.2015.02.004
DO - 10.1016/j.diii.2015.02.004
M3 - Article
C2 - 26361992
AN - SCOPUS:85016923899
SN - 2211-5684
VL - 97
SP - 57
EP - 63
JO - Diagnostic and interventional imaging
JF - Diagnostic and interventional imaging
IS - 1
ER -