Adrenergic sensitivity of the sensory receptors modulating mechanical allodynia in a rat neuropathic pain model

Dong Eon Moon, Doo Hyun Lee, Hee Chul Han, Jiangang Xie, Richard E. Coggeshall, Jin Mo Chung

    Research output: Contribution to journalArticlepeer-review

    49 Scopus citations

    Abstract

    This study focuses on changes in adrenergic sensitivity in untransected sensory axons that innervate an area of skin made neuropathic by transection of neighboring nerves. The segmental nerve injury model is favorable for this since all axons in the L5 and L6 nerves are transected whereas the L4 axons are intact. Earlier findings are that pain behaviors develop after this injury and that these beahviors are ameliorated by sympathectomy. The present study shows that behavior indicating mechanical allodynia can be rekindled after sympathectomy by intradermal norepinephrine and α-2 but not α-1 adrenergic ligands and the rekindling can be blocked by α-2 but not α-1 adrenergic antagonists. By contrast neither intradermal norepinephrine nor other adrenergic agonists or antagonists have any demonstrable effects in the normal or after either neuropathic surgery or sympathectomy alone. These data suggest that the combination of neuropathic surgery and sympathectomy results in an upregulation of active α-2 adrenergic receptors on the undamaged sensory axons that provide the remaining sensory innervation to a neuropathic area partially denervated by segmental nerve lesions. These changes on undamaged axons presumably compliment similar changes on the transected axons and, thus play a role in the development of neuropathic pain. Copyright (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

    Original languageEnglish (US)
    Pages (from-to)589-595
    Number of pages7
    JournalPain
    Volume80
    Issue number3
    DOIs
    StatePublished - Apr 1 1999

    Keywords

    • Causalgia
    • Segmental spinal nerve
    • Sympathectomy
    • Sympathetically maintained pain

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Anesthesiology and Pain Medicine

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