TY - JOUR
T1 - Adult adenovirus infections
T2 - Loss of orphaned vaccines precipitates military respiratory disease epidemics
AU - Gray, G. C.
AU - Goswami, P. R.
AU - Malasig, M. D.
AU - Hawksworth, A. W.
AU - Trump, D. H.
AU - Ryan, M. A.
AU - Schnurr, D. P.
N1 - Funding Information:
Received 3 March 2000; electronically published 4 October 2000. This research was done in compliance with all applicable federal regulations governing the protection of human subjects in research. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. This article is approved for public release with unlimited distribution. Financial support: Office of Naval Research, Arlington, VA (as report no. 99-28); Department of the Navy (under work unit no. 61102A0101.BKX .6425). a Current affiliation: Amsterdam Medical Center, University of Amsterdam, The Netherlands. b A list of Adenovirus Surveillance Group collaborators follows the text. Reprints or correspondence: Dr. G. C. Gray, Naval Health Research Center, Dept. of Defense Center for Deployment Health Research, P.O. Box 85122, San Diego, CA 92186-5122 ([email protected]).
PY - 2000
Y1 - 2000
N2 - Adenovirus vaccines have greatly reduced military respiratory disease morbidity since the 1970s. However, in 1995, for economic reasons, the sole manufacturer of these vaccines ceased production. A population-based adenovirus surveillance was established among trainees with acute respiratory illness at 4 US military training centers as the last stores of vaccines were depleted. From October 1996 to June 1998, 1814 (53.1%) of 3413 throat cultures for symptomatic trainees (78% men) yielded adenovirus. Adenovirus types 4, 7, 3, and 21 accounted for 57%, 25%, 9%, and 7% of the isolates, respectively. Unvaccinated trainees were much more likely than vaccinated trainees to be positive for types 4 or 7 (odds ratio [OR] = 28.1; 95% CI, 20.2-39.2). Two training centers experienced epidemics of respiratory disease affecting thousands of trainees when vaccines were not available. Until a new manufacturer is identified, the loss of orphaned adenovirus vaccines will result in thousands of additional preventable adenovirus infections.
AB - Adenovirus vaccines have greatly reduced military respiratory disease morbidity since the 1970s. However, in 1995, for economic reasons, the sole manufacturer of these vaccines ceased production. A population-based adenovirus surveillance was established among trainees with acute respiratory illness at 4 US military training centers as the last stores of vaccines were depleted. From October 1996 to June 1998, 1814 (53.1%) of 3413 throat cultures for symptomatic trainees (78% men) yielded adenovirus. Adenovirus types 4, 7, 3, and 21 accounted for 57%, 25%, 9%, and 7% of the isolates, respectively. Unvaccinated trainees were much more likely than vaccinated trainees to be positive for types 4 or 7 (odds ratio [OR] = 28.1; 95% CI, 20.2-39.2). Two training centers experienced epidemics of respiratory disease affecting thousands of trainees when vaccines were not available. Until a new manufacturer is identified, the loss of orphaned adenovirus vaccines will result in thousands of additional preventable adenovirus infections.
UR - https://www.scopus.com/pages/publications/0034456968
UR - https://www.scopus.com/pages/publications/0034456968#tab=citedBy
U2 - 10.1086/313999
DO - 10.1086/313999
M3 - Article
C2 - 11017812
AN - SCOPUS:0034456968
SN - 1058-4838
VL - 31
SP - 663
EP - 670
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -