Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens

Jennifer E. Peel; Elizabeth Jardinella; Yue Qu; Jessica Plante; Brooke M. Mitchell; Jordyn L. Walker; Roberto P. Garofalo; Scott C. Weaver; Kenneth S. Plante; Trevor Brasel; William S. Lawrence

doi:10.1016/j.ajic.2025.02.008

Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens

Jennifer E. Peel, Elizabeth Jardinella, Yue Qu, Jessica Plante, Brooke M. Mitchell, Jordyn L. Walker, Roberto P. Garofalo, Scott C. Weaver, Kenneth S. Plante, Trevor Brasel, William S. Lawrence

Research output: Contribution to journal › Article › peer-review

Abstract

Efficient, rapid means of air decontamination are needed against widespread respiratory pathogens such as SARS-CoV-2, the virus that causes COVID-19. This study demonstrated the efficacy of advanced photohydrolysis technology in significantly reducing infectious, aerosolized SARS-CoV-2, achieving over 99% viral inactivation. Proof-of-concept assessments for respiratory syncytial virus and monkeypox virus showed similar results, suggesting broad applicability. These findings highlight the potential of the novel technology to enhance air purification and infection control strategies against multiple airborne viral pathogens.

Original language	English (US)
Journal	American Journal of Infection Control
DOIs	https://doi.org/10.1016/j.ajic.2025.02.008
State	Accepted/In press - 2025

Keywords

Air purification
Infection control
Respiratory pathogens
Viral aerosols

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.ajic.2025.02.008

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Peel, J. E., Jardinella, E., Qu, Y., Plante, J., Mitchell, B. M., Walker, J. L., Garofalo, R. P., Weaver, S. C., Plante, K. S., Brasel, T., & Lawrence, W. S. (Accepted/In press). Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens. American Journal of Infection Control. https://doi.org/10.1016/j.ajic.2025.02.008

Peel, JE, Jardinella, E, Qu, Y, Plante, J, Mitchell, BM, Walker, JL, Garofalo, RP , Weaver, SC , Plante, KS, Brasel, T & Lawrence, WS 2025, 'Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens', American Journal of Infection Control. https://doi.org/10.1016/j.ajic.2025.02.008

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title = "Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens",

abstract = "Efficient, rapid means of air decontamination are needed against widespread respiratory pathogens such as SARS-CoV-2, the virus that causes COVID-19. This study demonstrated the efficacy of advanced photohydrolysis technology in significantly reducing infectious, aerosolized SARS-CoV-2, achieving over 99% viral inactivation. Proof-of-concept assessments for respiratory syncytial virus and monkeypox virus showed similar results, suggesting broad applicability. These findings highlight the potential of the novel technology to enhance air purification and infection control strategies against multiple airborne viral pathogens.",

keywords = "Air purification, Infection control, Respiratory pathogens, Viral aerosols",

author = "Peel, {Jennifer E.} and Elizabeth Jardinella and Yue Qu and Jessica Plante and Mitchell, {Brooke M.} and Walker, {Jordyn L.} and Garofalo, {Roberto P.} and Weaver, {Scott C.} and Plante, {Kenneth S.} and Trevor Brasel and Lawrence, {William S.}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

doi = "10.1016/j.ajic.2025.02.008",

language = "English (US)",

journal = "American Journal of Infection Control",

issn = "0196-6553",

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TY - JOUR

T1 - Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens

AU - Peel, Jennifer E.

AU - Jardinella, Elizabeth

AU - Qu, Yue

AU - Plante, Jessica

AU - Mitchell, Brooke M.

AU - Walker, Jordyn L.

AU - Garofalo, Roberto P.

AU - Weaver, Scott C.

AU - Plante, Kenneth S.

AU - Brasel, Trevor

AU - Lawrence, William S.

PY - 2025

Y1 - 2025

N2 - Efficient, rapid means of air decontamination are needed against widespread respiratory pathogens such as SARS-CoV-2, the virus that causes COVID-19. This study demonstrated the efficacy of advanced photohydrolysis technology in significantly reducing infectious, aerosolized SARS-CoV-2, achieving over 99% viral inactivation. Proof-of-concept assessments for respiratory syncytial virus and monkeypox virus showed similar results, suggesting broad applicability. These findings highlight the potential of the novel technology to enhance air purification and infection control strategies against multiple airborne viral pathogens.

AB - Efficient, rapid means of air decontamination are needed against widespread respiratory pathogens such as SARS-CoV-2, the virus that causes COVID-19. This study demonstrated the efficacy of advanced photohydrolysis technology in significantly reducing infectious, aerosolized SARS-CoV-2, achieving over 99% viral inactivation. Proof-of-concept assessments for respiratory syncytial virus and monkeypox virus showed similar results, suggesting broad applicability. These findings highlight the potential of the novel technology to enhance air purification and infection control strategies against multiple airborne viral pathogens.

KW - Air purification

KW - Infection control

KW - Respiratory pathogens

KW - Viral aerosols

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DO - 10.1016/j.ajic.2025.02.008

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SN - 0196-6553

JO - American Journal of Infection Control

JF - American Journal of Infection Control

ER -

Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens

Abstract

Keywords

ASJC Scopus subject areas

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