Advances and considerations in AD tau-targeted immunotherapy

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The multifactorial and complex nature of Alzheimer's disease (AD) has made it difficult to identify therapeutic targets that are causally involved in the disease process. However, accumulating evidence from experimental and clinical studies that investigate the early disease process point towards the required role of tau in AD etiology. Importantly, a large number of studies investigate and characterize the plethora of pathological forms of tau protein involved in disease onset and propagation. Immunotherapy is one of the most clinical approaches anticipated to make a difference in the field of AD therapeutics. Tau –targeted immunotherapy is the new direction after the failure of amyloid beta (Aß)-targeted immunotherapy and the growing number of studies that highlight the Aß-independent disease process. It is now well established that immunotherapy alone will most likely be insufficient as a monotherapy. Therefore, this review discusses updates on tau-targeted immunotherapy studies, AD-relevant tau species, updates on promising biomarkers and a prospect on combination therapies to surround the disease propagation in an efficient and timely manner.

Original languageEnglish (US)
Article number104707
JournalNeurobiology of Disease
Volume134
DOIs
StatePublished - Feb 2020

Keywords

  • Alzheimer's disease
  • Alzheimer's disease clinical trials
  • Amyloid Beta immunotherapy
  • Biomarkers
  • extracellular tau
  • Tau
  • Tau-targeted immunotherapy

ASJC Scopus subject areas

  • Neurology

Fingerprint Dive into the research topics of 'Advances and considerations in AD tau-targeted immunotherapy'. Together they form a unique fingerprint.

  • Cite this