Advances in preclinical investigation of prostate cancer gene therapy

Marxa L. Figueiredo, Chinghai Kao, Lily Wu

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Treating recurrent prostate cancer poses a great challenge to clinicians. Research efforts in the last decade have shown that adenoviral vector-based gene therapy is a promising approach that could expand the arsenal against prostate cancer. This maturing field is at the stage of being able to translate many preclinical discoveries into clinical practices. At this juncture, it is important to highlight the promising strategies including prostate-targeted gene expression, the use of oncolytic vectors, therapy coupled to reporter gene imaging, and combined treatment modalities. In fact, the early stages of clinical investigation employing combined, multimodal gene therapy focused on loco-regional tumor eradication and showed promising results. Clinicians and scientists should seize the momentum of progress to push forward to improve the therapeutic outcome for the patients.

Original languageEnglish (US)
Pages (from-to)1053-1064
Number of pages12
JournalMolecular Therapy
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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