Advances in therapeutics for neurodegenerative tauopathies

Moving toward the specific targeting of the most toxic tau species

Julia E. Gerson, Diana L. Castillo-Carranza, Rakez Kayed

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates - tau oligomers - are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)752-769
Number of pages18
JournalACS Chemical Neuroscience
Volume5
Issue number9
DOIs
StatePublished - Sep 17 2014

Fingerprint

Tauopathies
Neurodegenerative diseases
Molecular Chaperones
Poisons
Pathology
Oligomers
Agglomeration
Modulation
Health
Molecules
Neurofibrillary Tangles
Post Translational Protein Processing
Neurodegenerative Diseases
Immunotherapy
Therapeutics
Research Personnel
Direction compound

Keywords

  • Immunotherapy
  • Molecular chaperones
  • Oligomers
  • Small molecules

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Cognitive Neuroscience

Cite this

Advances in therapeutics for neurodegenerative tauopathies : Moving toward the specific targeting of the most toxic tau species. / Gerson, Julia E.; Castillo-Carranza, Diana L.; Kayed, Rakez.

In: ACS Chemical Neuroscience, Vol. 5, No. 9, 17.09.2014, p. 752-769.

Research output: Contribution to journalArticle

@article{094f0f2e631443a19e1ab180561a0c9f,
title = "Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species",
abstract = "Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates - tau oligomers - are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions. (Figure Presented).",
keywords = "Immunotherapy, Molecular chaperones, Oligomers, Small molecules",
author = "Gerson, {Julia E.} and Castillo-Carranza, {Diana L.} and Rakez Kayed",
year = "2014",
month = "9",
day = "17",
doi = "10.1021/cn500143n",
language = "English (US)",
volume = "5",
pages = "752--769",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Advances in therapeutics for neurodegenerative tauopathies

T2 - Moving toward the specific targeting of the most toxic tau species

AU - Gerson, Julia E.

AU - Castillo-Carranza, Diana L.

AU - Kayed, Rakez

PY - 2014/9/17

Y1 - 2014/9/17

N2 - Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates - tau oligomers - are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions. (Figure Presented).

AB - Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates - tau oligomers - are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions. (Figure Presented).

KW - Immunotherapy

KW - Molecular chaperones

KW - Oligomers

KW - Small molecules

UR - http://www.scopus.com/inward/record.url?scp=84924980333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924980333&partnerID=8YFLogxK

U2 - 10.1021/cn500143n

DO - 10.1021/cn500143n

M3 - Article

VL - 5

SP - 752

EP - 769

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

SN - 1948-7193

IS - 9

ER -