Advantages of the Papillon protocol in the preoperative treatment of rectal carcinoma

Vicki Klimberg, James D. Langston, Ann Maners, John C. Gocio, Laura F. Hutchins, Nicholas P. Lang, Kent C. Westbrook, John R. Broadwater

Research output: Contribution to journalArticle

Abstract

Standard treatment for advanced rectal carcinoma currently includes surgery, radiotherapy, and chemotherapy. Although there are theoretic advantages to preoperative irradiation, it is often not performed because of the prolonged delay of surgery and the purported increase in perioperative complications. A pilot study was undertaken at our institution to evaluate a treatment protocol advocated by Dr. Papillon that offers a shorter treatment time and less patient morbidity than conventional preoperative therapy for rectal carcinoma. Twenty patients with rectal cancer underwent the preoperative regimen that consisted of 3,000 cGy delivered in 10 fractions over 12 days with concomitant 5-fluorouracil and mitomycin-C. Complications were acceptable. Local recurrence was lower than in most reported trials, and survival rates were comparable. Additional benefits of the protocol include lower radiation morbidity to the patient and a decreased delay between diagnosis and surgery.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalThe American Journal of Surgery
Volume164
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Klimberg, V., Langston, J. D., Maners, A., Gocio, J. C., Hutchins, L. F., Lang, N. P., Westbrook, K. C., & Broadwater, J. R. (1992). Advantages of the Papillon protocol in the preoperative treatment of rectal carcinoma. The American Journal of Surgery, 164(5), 433-436. https://doi.org/10.1016/S0002-9610(05)81175-4