Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre-existing chronic hydrocephalus

Tiffany A. Peterson, Andrew G. MacLean, Kasi E. Russell-Lodrigue, Peter J. Didier, Scott C. Weaver, Chad J. Roy

Research output: Contribution to journalArticle

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Abstract

A cynomolgus macaque (Macaca fascicularis) with a pre-existing, undiagnosed, subclinical but severe cerebral hydrocephalus was enrolled in a study of long-term immunogenicity of the IRES/CHIK vaccine. The animal began showing signs of neurological dysfunction post-vaccination, which progressed and ultimately resulted in euthanasia. The underlying brain abnormality was revealed at necropsy and was subsequently investigated with gross and microscopic examination. This becomes the first reported case of an adverse event following administration of a live attenuated vaccine and suggests the possibility of an increased susceptibility risk of unwanted adverse outcome associated with vaccination in populations with pre-existing conditions such as hydrocephalus.

Original languageEnglish (US)
Pages (from-to)257-259
Number of pages3
JournalJournal of Medical Primatology
Volume48
Issue number4
DOIs
StatePublished - Aug 2019

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Keywords

  • cynomolgus macaque
  • hydrocephalus
  • live attenuated viral vaccine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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