Adverse reactions to fluorescein angiography: A comprehensive review of the literature

Ilyse S. Kornblau, Jaafar El-Annan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We reviewed literature on adverse reactions to intravenous fluorescein angiography using PubMed and found 78 articles in English from 1961 to 2017. The reported rates of adverse reactions were overall 0.083–21.69%, separated into mild (1.24–17.65%), moderate (0.2–6%), and severe (0.04–0.59%). There were 1:100,000 to 1:220,000 deaths. Fluorescein concentration, volume injected, speed of injection, temperature, and contaminants were not correlated with the incidence of reactions. Patient characteristics including other comorbid diseases, allergy history, age, race, and gender showed only an increased rate of reaction in patients with a history of reaction to fluorescein. Although a number of studies examine techniques to reduce adverse reactions to intravenous fluorescein angiography, to date, the only proven method is reviewing allergy history, specifically a history of previous reaction to fluorescein.

Original languageEnglish (US)
JournalSurvey of Ophthalmology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Fluorescein Angiography
Fluorescein
Hypersensitivity
PubMed
Injections
Temperature
Incidence

Keywords

  • adverse reactions
  • allergy
  • anaphylaxis
  • drug toxicity
  • fluorescein angiography
  • medication reactions

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Adverse reactions to fluorescein angiography : A comprehensive review of the literature. / Kornblau, Ilyse S.; El-Annan, Jaafar.

In: Survey of Ophthalmology, 01.01.2019.

Research output: Contribution to journalArticle

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