Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls

George P. Nassis, Katerina Papantakou, Katerina Skenderi, Maria Triandafillopoulou, Stavros A. Kavouras, Mary Yannakoulia, George P. Chrousos, Labros S. Sidossis

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to examine the effect of aerobic exercise training on insulin sensitivity in overweight and obese girls. Nineteen overweight and obese girls (mean ± SD: age, 13.1 ± 1.8 years; body mass index, 26.8 ± 3.9 kg/m2) volunteered for this study. Body composition (dual-energy x-ray absorptiometry), insulin sensitivity (oral glucose tolerance test and homeostasis model assessment estimate of insulin resistance; n = 15), adiponectin, C-reactive protein (CRP), interleukin (IL) 6, insulin-like growth factor-1, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 serum levels, and blood lipids and lipoproteins were assessed before and after 12 weeks of aerobic training. Cardiorespiratory fitness increased by 18.8% (P < .05) as a result of training. The area under the insulin concentration curve (insulin area under the curve) decreased by 23.3% (12 781.7 ± 7454.2 vs 9799.0 ± 4918.6 μU·min/mL before and after intervention, respectively; P = .03). Insulin sensitivity was improved without changes in body weight (preintervention, 67.9 ± 14.5 kg; postintervention, 68.3 ± 14.0 kg) or percent body fat (preintervention, 41.4% ± 4.8%; postintervention, 40.7% ± 5.2%). The lower limb fat-free mass increased by 6.2% (P < .01) as a result of training, and changes in lower limb fat-free mass were correlated with changes in the insulin area under the curve (r = -.68; P < .01). Serum adiponectin, IL-6, and CRP concentrations did not change (preintervention vs postintervention: adiponectin, 9.57 ± 3.01 vs 9.08 ± 2.32 μg/mL; IL-6, 1.67 ± 1.29 vs 1.65 ± 1.25 pg/mL, CRP, 3.21 ± 2.48 vs 2.73 ± 1.88 mg/L) whereas insulin-like growth factor-1 was lower after training (preintervention, 453.8 ± 159.3 ng/mL; postintervention, 403.2 ± 155.1 ng/mL; P < .05). In conclusion, 12 weeks of aerobic training improved insulin sensitivity in overweight and obese girls without change in body weight, percent body fat, and circulating concentrations of adiponectin, IL-6, CRP, and other inflammatory markers. These findings suggest that increased physical activity may ameliorate the metabolic abnormalities associated with obesity in children with a mechanism other than the parameters cited earlier.

Original languageEnglish (US)
Pages (from-to)1472-1479
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume54
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Body Weight Changes
Adiponectin
Insulin Resistance
Adipose Tissue
C-Reactive Protein
Exercise
Interleukin-6
Somatomedins
Insulin
Area Under Curve
Lower Extremity
Fats
Vascular Cell Adhesion Molecule-1
Pediatric Obesity
Intercellular Adhesion Molecule-1
Glucose Tolerance Test
Body Composition
Serum
Lipoproteins
Body Mass Index

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. / Nassis, George P.; Papantakou, Katerina; Skenderi, Katerina; Triandafillopoulou, Maria; Kavouras, Stavros A.; Yannakoulia, Mary; Chrousos, George P.; Sidossis, Labros S.

In: Metabolism: Clinical and Experimental, Vol. 54, No. 11, 11.2005, p. 1472-1479.

Research output: Contribution to journalArticle

Nassis, GP, Papantakou, K, Skenderi, K, Triandafillopoulou, M, Kavouras, SA, Yannakoulia, M, Chrousos, GP & Sidossis, LS 2005, 'Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls', Metabolism: Clinical and Experimental, vol. 54, no. 11, pp. 1472-1479. https://doi.org/10.1016/j.metabol.2005.05.013
Nassis, George P. ; Papantakou, Katerina ; Skenderi, Katerina ; Triandafillopoulou, Maria ; Kavouras, Stavros A. ; Yannakoulia, Mary ; Chrousos, George P. ; Sidossis, Labros S. / Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. In: Metabolism: Clinical and Experimental. 2005 ; Vol. 54, No. 11. pp. 1472-1479.
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T1 - Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls

AU - Nassis, George P.

AU - Papantakou, Katerina

AU - Skenderi, Katerina

AU - Triandafillopoulou, Maria

AU - Kavouras, Stavros A.

AU - Yannakoulia, Mary

AU - Chrousos, George P.

AU - Sidossis, Labros S.

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N2 - The aim of this study was to examine the effect of aerobic exercise training on insulin sensitivity in overweight and obese girls. Nineteen overweight and obese girls (mean ± SD: age, 13.1 ± 1.8 years; body mass index, 26.8 ± 3.9 kg/m2) volunteered for this study. Body composition (dual-energy x-ray absorptiometry), insulin sensitivity (oral glucose tolerance test and homeostasis model assessment estimate of insulin resistance; n = 15), adiponectin, C-reactive protein (CRP), interleukin (IL) 6, insulin-like growth factor-1, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 serum levels, and blood lipids and lipoproteins were assessed before and after 12 weeks of aerobic training. Cardiorespiratory fitness increased by 18.8% (P < .05) as a result of training. The area under the insulin concentration curve (insulin area under the curve) decreased by 23.3% (12 781.7 ± 7454.2 vs 9799.0 ± 4918.6 μU·min/mL before and after intervention, respectively; P = .03). Insulin sensitivity was improved without changes in body weight (preintervention, 67.9 ± 14.5 kg; postintervention, 68.3 ± 14.0 kg) or percent body fat (preintervention, 41.4% ± 4.8%; postintervention, 40.7% ± 5.2%). The lower limb fat-free mass increased by 6.2% (P < .01) as a result of training, and changes in lower limb fat-free mass were correlated with changes in the insulin area under the curve (r = -.68; P < .01). Serum adiponectin, IL-6, and CRP concentrations did not change (preintervention vs postintervention: adiponectin, 9.57 ± 3.01 vs 9.08 ± 2.32 μg/mL; IL-6, 1.67 ± 1.29 vs 1.65 ± 1.25 pg/mL, CRP, 3.21 ± 2.48 vs 2.73 ± 1.88 mg/L) whereas insulin-like growth factor-1 was lower after training (preintervention, 453.8 ± 159.3 ng/mL; postintervention, 403.2 ± 155.1 ng/mL; P < .05). In conclusion, 12 weeks of aerobic training improved insulin sensitivity in overweight and obese girls without change in body weight, percent body fat, and circulating concentrations of adiponectin, IL-6, CRP, and other inflammatory markers. These findings suggest that increased physical activity may ameliorate the metabolic abnormalities associated with obesity in children with a mechanism other than the parameters cited earlier.

AB - The aim of this study was to examine the effect of aerobic exercise training on insulin sensitivity in overweight and obese girls. Nineteen overweight and obese girls (mean ± SD: age, 13.1 ± 1.8 years; body mass index, 26.8 ± 3.9 kg/m2) volunteered for this study. Body composition (dual-energy x-ray absorptiometry), insulin sensitivity (oral glucose tolerance test and homeostasis model assessment estimate of insulin resistance; n = 15), adiponectin, C-reactive protein (CRP), interleukin (IL) 6, insulin-like growth factor-1, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 serum levels, and blood lipids and lipoproteins were assessed before and after 12 weeks of aerobic training. Cardiorespiratory fitness increased by 18.8% (P < .05) as a result of training. The area under the insulin concentration curve (insulin area under the curve) decreased by 23.3% (12 781.7 ± 7454.2 vs 9799.0 ± 4918.6 μU·min/mL before and after intervention, respectively; P = .03). Insulin sensitivity was improved without changes in body weight (preintervention, 67.9 ± 14.5 kg; postintervention, 68.3 ± 14.0 kg) or percent body fat (preintervention, 41.4% ± 4.8%; postintervention, 40.7% ± 5.2%). The lower limb fat-free mass increased by 6.2% (P < .01) as a result of training, and changes in lower limb fat-free mass were correlated with changes in the insulin area under the curve (r = -.68; P < .01). Serum adiponectin, IL-6, and CRP concentrations did not change (preintervention vs postintervention: adiponectin, 9.57 ± 3.01 vs 9.08 ± 2.32 μg/mL; IL-6, 1.67 ± 1.29 vs 1.65 ± 1.25 pg/mL, CRP, 3.21 ± 2.48 vs 2.73 ± 1.88 mg/L) whereas insulin-like growth factor-1 was lower after training (preintervention, 453.8 ± 159.3 ng/mL; postintervention, 403.2 ± 155.1 ng/mL; P < .05). In conclusion, 12 weeks of aerobic training improved insulin sensitivity in overweight and obese girls without change in body weight, percent body fat, and circulating concentrations of adiponectin, IL-6, CRP, and other inflammatory markers. These findings suggest that increased physical activity may ameliorate the metabolic abnormalities associated with obesity in children with a mechanism other than the parameters cited earlier.

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