TY - JOUR
T1 - Age-Related Alterations in Mesenchymal Stem Cell Function
T2 - Understanding Mechanisms and Seeking Opportunities to Bypass the Cellular Aging
AU - Rasouli, Mehdi
AU - Naeimzadeh, Yasaman
AU - Hashemi, Nader
AU - Hosseinzadeh, Simzar
N1 - Publisher Copyright:
© 2024 Bentham Science Publishers.
PY - 2024
Y1 - 2024
N2 - Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy candidates in clinical research and therapy. They not only exert considerable therapeutic effects to alleviate inflammation and promote regeneration, but also show low-immunogenicity properties, which ensure their safety following allogeneic transplantation. Thanks to the necessity of providing a sufficient number of MSCs to achieve clinically efficient outcomes, prolonged in vitro cultivation is indisputable. However, either following long-term in vitro expansion or aging in elderly individuals, MSCs face cellular senescence. Senescent MSCs undergo an impairment in their function and therapeutic capacities and secrete degenerative factors which negatively affect young MSCs. To this end, designing novel investigations to further elucidate cellular senescence and to pave the way toward finding new strategies to reverse senescence is highly demanded. In this review, we will concisely discuss current progress on the detailed mechanisms of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised therapeutic efficacy of the senescent MSCs.
AB - Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy candidates in clinical research and therapy. They not only exert considerable therapeutic effects to alleviate inflammation and promote regeneration, but also show low-immunogenicity properties, which ensure their safety following allogeneic transplantation. Thanks to the necessity of providing a sufficient number of MSCs to achieve clinically efficient outcomes, prolonged in vitro cultivation is indisputable. However, either following long-term in vitro expansion or aging in elderly individuals, MSCs face cellular senescence. Senescent MSCs undergo an impairment in their function and therapeutic capacities and secrete degenerative factors which negatively affect young MSCs. To this end, designing novel investigations to further elucidate cellular senescence and to pave the way toward finding new strategies to reverse senescence is highly demanded. In this review, we will concisely discuss current progress on the detailed mechanisms of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised therapeutic efficacy of the senescent MSCs.
KW - cellular aging
KW - cellular senescence
KW - Mesenchymal stem cell
KW - pro-inflammatory cytokines
KW - reactive oxygen species (ROS)
KW - rejuvenation
KW - therapeutic efficacy
UR - http://www.scopus.com/inward/record.url?scp=85147867547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85147867547&partnerID=8YFLogxK
U2 - 10.2174/1574888X18666230113144016
DO - 10.2174/1574888X18666230113144016
M3 - Review article
AN - SCOPUS:85147867547
SN - 1574-888X
VL - 19
SP - 15
EP - 32
JO - Current Stem Cell Research and Therapy
JF - Current Stem Cell Research and Therapy
IS - 1
ER -